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1. WO2020207355 - PHARMACEUTICAL COMPOSITION CONTAINING AMLODIPINE, CHLORTHALIDONE, AND AMILORIDE

Publication Number WO/2020/207355
Publication Date 15.10.2020
International Application No. PCT/CN2020/083332
International Filing Date 03.04.2020
IPC
A61K 31/4965 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
33Heterocyclic compounds
395having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
495having six-membered rings with two nitrogen atoms as the only ring hetero atoms, e.g. piperazine
4965Non-condensed pyrazines
A61P 9/12 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
9Drugs for disorders of the cardiovascular system
12Antihypertensives
A61P 9/10 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
9Drugs for disorders of the cardiovascular system
10for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
A61P 9/00 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
9Drugs for disorders of the cardiovascular system
A61P 13/12 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
13Drugs for disorders of the urinary system
12of the kidneys
A61P 7/04 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
7Drugs for disorders of the blood or the extracellular fluid
04Antihaemorrhagics; Procoagulants; Haemostatatic agents; Antifibrinolytic agents
Applicants
  • 深圳奥萨医药有限公司 SHENZHEN AUSA PHARMED CO., LTD. [CN]/[CN]
  • 深圳奥萨制药有限公司 SHENZHEN AUSA PHARMACEUTICAL CO., LTD. [CN]/[CN]
Inventors
  • 陈光亮 CHEN, Guangliang
  • 于多 YU, Duo
  • 白洁 BAI, Jie
  • 田敏卿 TIAN, Minqing
  • 陈平 CHEN, Ping
  • 徐希平 XU, Xiping
Priority Data
201910274749.808.04.2019CN
Publication Language Chinese (ZH)
Filing Language Chinese (ZH)
Designated States
Title
(EN) PHARMACEUTICAL COMPOSITION CONTAINING AMLODIPINE, CHLORTHALIDONE, AND AMILORIDE
(FR) COMPOSITION PHARMACEUTIQUE CONTENANT DE L'AMLODIPINE, DE LA CHLORTALIDONE ET DE L'AMILORIDE
(ZH) 含氨氯地平、氯噻酮和阿米洛利的药物组合物
Abstract
(EN)
Provided is a pharmaceutical composition for treating refractory hypertension. The pharmaceutical composition consists of amlodipine, chlorthalidone, and amiloride. The provided pharmaceutical composition provides an effective antihypertensive drug for patients with refractory hypertension, especially refractory hypertension patients with low renin/low aldosterone, and the provided pharmaceutical composition can also enhance the protective effect on the target organs of patients with refractory hypertension and reduce the risk of cerebrovascular events.
(FR)
L'invention concerne une composition pharmaceutique pour le traitement de l'hypertension réfractaire. La composition pharmaceutique comprend de l'amlodipine, de la chlortalidone et de l'amiloride. La composition pharmaceutique selon l'invention fournit un médicament antihypertenseur efficace chez des patients atteints d'hypertension réfractaire, en particulier des patients atteints d'hypertension réfractaire avec un faible taux de rénine et d'aldostérone, et elle peut également améliorer l'effet de protection sur les organes cibles des patients atteints d'hypertension réfractaire et réduire le risque d'accidents vasculaires cérébraux.
(ZH)
提供一种治疗难治性高血压的药物组合物,由氨氯地平、氯噻酮和阿米洛利组成。提供的药物组合物针对难治性高血压患者,尤其是低肾素/低醛固酮型的难治性高血压患者提供一种有效的降压药物,同时提供的药物组合物还可加强对难治性高血压患者靶器官的保护作用,降低脑血管事件危险性。
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