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1. WO2020206896 - METHOD FOR SCREENING MOLECULAR MARKER OF CATTLE ADAPTING TO HIGH ALTITUDE HYPOXIA AND APPLICATION THEREOF

Publication Number WO/2020/206896
Publication Date 15.10.2020
International Application No. PCT/CN2019/101460
International Filing Date 20.08.2019
IPC
C12Q 1/6811 2018.01
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
1Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
68involving nucleic acids
6811Selection methods for production or design of target specific oligonucleotides or binding molecules
C12Q 1/6888 2018.01
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
1Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
68involving nucleic acids
6876Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
6888for detection or identification of organisms
G16B 20/20 2019.01
GPHYSICS
16INFORMATION AND COMMUNICATION TECHNOLOGY SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
BBIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
20ICT specially adapted for functional genomics or proteomics, e.g. genotype-phenotype associations
20Allele or variant detection, e.g. single nucleotide polymorphism detection
CPC
C12Q 1/6811
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS
1Measuring or testing processes involving enzymes, nucleic acids or microorganisms
68involving nucleic acids
6811Selection methods for production or design of target specific oligonucleotides or binding molecules
C12Q 1/6888
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS
1Measuring or testing processes involving enzymes, nucleic acids or microorganisms
68involving nucleic acids
6876Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
6888for detection or identification of organisms
C12Q 2600/124
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS
2600Oligonucleotides characterized by their use
124Animal traits, i.e. production traits, including athletic performance or the like
C12Q 2600/156
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS
2600Oligonucleotides characterized by their use
156Polymorphic or mutational markers
Applicants
  • 山东省农业科学院奶牛研究中心 DAIRY CATTLE RESEARCH CENTER, SHANDONG ACADEMY OF AGRICULTURAL SCIENCE [CN]/[CN]
  • 山东奥克斯畜牧种业有限公司 SHANDONG OX LIVESTOCK BREEDING CO., LTD. [CN]/[CN]
Inventors
  • 黄金明 HUANG, Jinming
  • 赵晗 ZHAO, Han
  • 王秀革 WANG, Xiuge
  • 鞠志花 JU, Zhihua
  • 姜强 JIANG, Qiang
  • 王金鹏 WANG, Jinpeng
  • 张亚冉 ZHANG, Yaran
  • 刘勇 LIU, Yong
  • 魏晓超 WEI, Xiaochao
  • 高亚平 GAO, Yaping
  • 刘文浩 LIU, Wenhao
  • 王玲玲 WANG, Lingling
  • 高运东 GAO, Yundong
Agents
  • 济南圣达知识产权代理有限公司 JINAN SHENGDA INTELLECTUAL PROPERTY AGENCY CO., LTD.
Priority Data
201910280882.409.04.2019CN
Publication Language Chinese (ZH)
Filing Language Chinese (ZH)
Designated States
Title
(EN) METHOD FOR SCREENING MOLECULAR MARKER OF CATTLE ADAPTING TO HIGH ALTITUDE HYPOXIA AND APPLICATION THEREOF
(FR) PROCÉDÉ DE CRIBLAGE DE MARQUEUR MOLÉCULAIRE DE BÉTAIL S'ADAPTANT À L'HYPOXIE À HAUTE ALTITUDE ET SON APPLICATION
(ZH) 一种筛选牛高原低氧适应分子标记的方法及其应用
Abstract
(EN)
Provided are a method for screening a specific molecular marker of cattle adapting to high altitude hypoxia, and use of the specific marker in screening cattle breeds or individuals suitable for survival in high altitude hypoxia. For the genetic characteristics of adaptation of cattle breeds to high altitude hypoxia, from the perspective of genome evolution, selection and adaptation, local cattle breeds distributed at high and low altitudes are selected, and multi-genome-selection-signal and genome-wide association analysis methods and strategies are integrated to screen a key gene and a molecular marker adapting to high altitude hypoxia. The detection method designed according to the key gene and the marker features high accuracy and easy operation during application. By the analysis of cattle breeds at different altitudes, gene ACSS2 related to adaptation to high altitude hypoxia and a haplotype thereof are found, and specific SNP that receives the strongest selection signal on the gene is located. The method has great significance and practical value for cattle molecule breeding.
(FR)
L'invention concerne un procédé de criblage d'un marqueur moléculaire spécifique de bétail s'adaptant à l'hypoxie à haute altitude, et l'utilisation du marqueur spécifique dans le criblage de prélèvements de bétail ou d'individus appropriés pour la survie dans des conditions d'hypoxie à haute altitude. Pour les caractéristiques génétiques d'adaptation de breuvres de bétail à l'hypoxie à haute altitude, depuis la perspective de l'évolution, de la sélection et de l'adaptation du génome, des espèces de bétail locales distribuées à des altitudes élevées et basses sont sélectionnées, et des procédés et des stratégies d'analyse d'association à l'échelle du génome et du signal de sélection multi-génome sont intégrés pour cribler un gène clé et un marqueur moléculaire s'adaptant à l'hypoxie à haute altitude. Le procédé de détection conçu selon le gène clé et le marqueur présente une grande précision et un fonctionnement facile pendant l'application. Par l'analyse de prélèvements de bétail à différentes altitudes, le gène ACSS2 lié à l'adaptation à l'hypoxie à haute altitude et un haplotype correspondant sont trouvés, et un SNP spécifique qui reçoit le signal de sélection le plus fort sur le gène est situé. Le procédé présente une grande importance et une grande valeur pratique pour l'élevage de la molécule du bétail.
(ZH)
提供一种筛选牛高原低氧适应特异分子标记的方法,并通过这一特异标记筛选适合高原低氧生存的牛品种或者个体。针对牛品种高原低氧适应的遗传特性,从基因组进化、选择和适应的角度,选择分布于高、地海拔的地方牛品种,整合多种基因组选择信号和全基因组关联分析方法和策略,筛选适应高原低氧的关键基因和分子标记,依据关键基因和标记设计的检测方法,具有准确性高、应用操作简便的特点,通过对不同海拔牛品种进行分析发现了与高原低氧适应有关的基因ACSS2及其单倍型,并定位了该基因上受到最强选择信号的特异SNP,对于牛分子育种工作具有重要意义和实用价值。
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