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1. WO2020206420 - ANGULAR DEPTH RESOLVED RAMAN SPECTROSCOPY APPARATUS AND METHOD

Publication Number WO/2020/206420
Publication Date 08.10.2020
International Application No. PCT/US2020/026864
International Filing Date 06.04.2020
IPC
G01N 21/65 2006.01
GPHYSICS
01MEASURING; TESTING
NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
21Investigating or analysing materials by the use of optical means, i.e. using infra-red, visible or ultra-violet light
62Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
63optically excited
65Raman scattering
A61B 5/1455 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
BDIAGNOSIS; SURGERY; IDENTIFICATION
5Measuring for diagnostic purposes; Identification of persons
145Measuring characteristics of blood in vivo, e.g. gas concentration, pH-value
1455using optical sensors, e.g. spectral photometrical oximeters
G01J 3/32 2006.01
GPHYSICS
01MEASURING; TESTING
JMEASUREMENT OF INTENSITY, VELOCITY, SPECTRAL CONTENT, POLARISATION, PHASE OR PULSE CHARACTERISTICS OF INFRA-RED, VISIBLE OR ULTRA-VIOLET LIGHT; COLORIMETRY; RADIATION PYROMETRY
3Spectrometry; Spectrophotometry; Monochromators; Measuring colours
28Investigating the spectrum
30Measuring the intensity of spectral lines directly on the spectrum itself
32Investigating bands of a spectrum in sequence by a single detector
G01J 3/42 2006.01
GPHYSICS
01MEASURING; TESTING
JMEASUREMENT OF INTENSITY, VELOCITY, SPECTRAL CONTENT, POLARISATION, PHASE OR PULSE CHARACTERISTICS OF INFRA-RED, VISIBLE OR ULTRA-VIOLET LIGHT; COLORIMETRY; RADIATION PYROMETRY
3Spectrometry; Spectrophotometry; Monochromators; Measuring colours
28Investigating the spectrum
42Absorption spectrometry; Double-beam spectrometry; Flicker spectrometry; Reflection spectrometry
G01J 3/44 2006.01
GPHYSICS
01MEASURING; TESTING
JMEASUREMENT OF INTENSITY, VELOCITY, SPECTRAL CONTENT, POLARISATION, PHASE OR PULSE CHARACTERISTICS OF INFRA-RED, VISIBLE OR ULTRA-VIOLET LIGHT; COLORIMETRY; RADIATION PYROMETRY
3Spectrometry; Spectrophotometry; Monochromators; Measuring colours
28Investigating the spectrum
44Raman spectrometry; Scattering spectrometry
G01N 21/00 2006.01
GPHYSICS
01MEASURING; TESTING
NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
21Investigating or analysing materials by the use of optical means, i.e. using infra-red, visible or ultra-violet light
Applicants
  • CYTOVERIS INC. [US]/[US]
Inventors
  • ZHENG, Guoan
  • KERSEY, Alan
  • PANDEY, Rishikesh
  • FOURNIER, David
Agents
  • GETZ, Richard
Priority Data
62/829,87705.04.2019US
Publication Language English (EN)
Filing Language English (EN)
Designated States
Title
(EN) ANGULAR DEPTH RESOLVED RAMAN SPECTROSCOPY APPARATUS AND METHOD
(FR) APPAREIL ET PROCÉDÉ DE SPECTROSCOPIE RAMAN À RÉSOLUTION DE PROFONDEUR ANGULAIRE
Abstract
(EN)
An apparatus and method for analyzing a tissue sample to provide depth-selective information includes at least one light source, collection light optics, and a light detector. The light source is configured to produce a light beam having one or more wavelengths of light that cause a tissue sample to produce Raman light signals upon interrogation of the tissue sample. The light beam is oriented to impinge on an exposed surface of the tissue sample at a point of incidence (POI), and oriented so that the light beam enters the tissue sample at an oblique angle relative to the exposed surface of the tissue sample. The collection light optics are configured to collect the Raman light signals emanating from the tissue sample at one or more predetermined lateral distances from the point of incidence. The light detector is configured to receive the Raman light signals from the collection light optics.
(FR)
L'invention concerne un appareil et un procédé d'analyse d'un échantillon de tissu destinés à fournir des informations sélectives en profondeur qui comprennent au moins une source de lumière, des optiques de lumière de collecte et un détecteur de lumière. La source de lumière est conçue pour produire un faisceau de lumière comportant une ou plusieurs longueurs d'onde de lumière qui amènent un échantillon de tissu à produire des signaux de lumière Raman lors de l'interrogation de l'échantillon de tissu. Le faisceau de lumière est orienté de façon à frapper une surface exposée de l'échantillon de tissu au niveau d'un point d'incidence (POI), et orienté de telle sorte qu'il entre dans l'échantillon de tissu selon un angle oblique par rapport à la surface exposée de l'échantillon de tissu. Les optiques de lumière de collecte sont conçues pour collecter les signaux de lumière Raman émanant de l'échantillon de tissu à une ou plusieurs distances latérales prédéfinies par rapport au point d'incidence. Le détecteur de lumière est conçu pour recevoir les signaux de lumière Raman provenant des optiques de lumière de collecte.
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