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1. WO2020206314 - LIPOSOMES ENCAPSULATING ADENOSINE

Publication Number WO/2020/206314
Publication Date 08.10.2020
International Application No. PCT/US2020/026658
International Filing Date 03.04.2020
IPC
A61K 31/7048 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
70Carbohydrates; Sugars; Derivatives thereof
7042Compounds having saccharide radicals and heterocyclic rings
7048having oxygen as a ring hetero atom, e.g. leucoglucosan, hesperidin, erythromycin, nystatin
A61K 33/24 2019.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
33Medicinal preparations containing inorganic active ingredients
24Heavy metals; Compounds thereof
A61K 47/48 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
47Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
48the non-active ingredient being chemically bound to the active ingredient, e.g. polymer drug conjugates
Applicants
  • NEW YORK UNIVERSITY [US]/[US]
Inventors
  • ANGLE, Siddhesh, R.
  • CORCIULO, Carmen
  • CRONSTEIN, Bruce, N.
  • KAUFMAN, Jonathan
Agents
  • DIMAIO, John, T. M.
  • KADLE, Ranjana
  • LOPINSKI, John, D.
  • ROMAN, Paul, J.
  • WATT, Rachel, S.
Priority Data
62/828,91603.04.2019US
Publication Language English (EN)
Filing Language English (EN)
Designated States
Title
(EN) LIPOSOMES ENCAPSULATING ADENOSINE
(FR) LIPOSOMES ENCAPSULANT DE L'ADÉNOSINE
Abstract
(EN)
Provided are liposomes that encapsulate adenosine. The liposomes may be formed from sphingomyelin or a combination of sphingomyelin and l,2-dimyristoyl-sn-glycero-3-phosphocholine (DMPC) or a combination of sphingomyelin and l,2-dimyristoyl-sn-glycero-3-phosphorylglycerol (DMPG) or a combination of sphingomyelin, DMPG, and DMPC. The liposomes encapsulating adenosine may be used to induce cartilage regeneration, treat osteoarthritis, alleviate joint pain, and/or slow, arrest, and/or reverse progressive structural tissue damage associated with osteoarthritis or treat osteoarthritis, rheumatoid arthritis, acute gouty arthritis, and/or synovitis. The liposomes may release adenosine for up to two weeks.
(FR)
L'invention concerne des liposomes qui encapsulent de l'adénosine. Les liposomes peuvent être formés à partir de sphingomyéline ou d'une combinaison de sphingomyéline et de 1,2-dimyristoyl-sn-glycéro-3-phosphocholine (DMPC) ou d'une combinaison de sphingomyéline et de 1,2-dimyristoyl-sn-glycéro-3-phosphorylglycérol (DMPG) ou d'une combinaison de sphingomyéline, de DMPG et de DMPC. Les liposomes encapsulant l'adénosine peuvent être utilisés pour induire une régénération cartilagineuse, traiter l'ostéoarthrite, atténuer la douleur articulaire, et/ou ralentir, arrêter et/ou inverser les lésions tissulaire structurales progressives associées à l'ostéoarthrite, ou traiter l'ostéoarthrite, la polyarthrite rhumatoïde, la goutte articulaire aiguë et/ou la synovite. Les liposomes peuvent libérer de l'adénosine pendant jusqu'à deux semaines.
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