Processing

Please wait...

Settings

Settings

Goto Application

1. WO2020206187 - ENGINEERED SYSTEM OF STEM CELL REJUVENATION TO TREAT AGING AND DISEASE

Publication Number WO/2020/206187
Publication Date 08.10.2020
International Application No. PCT/US2020/026483
International Filing Date 02.04.2020
IPC
A01N 63/00 2020.01
AHUMAN NECESSITIES
01AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
NPRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
63Biocides, pest repellants or attractants, or plant growth regulators containing microorganisms, viruses, microbial fungi, animals or substances produced by, or obtained from, microorganisms, viruses, microbial fungi or animals, e.g. enzymes or fermentates
A61K 31/7088 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
70Carbohydrates; Sugars; Derivatives thereof
7088Compounds having three or more nucleosides or nucleotides
A61K 35/12 2015.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
35Medicinal preparations containing materials or reaction products thereof with undetermined constitution
12Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
A61K 35/545 2015.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
35Medicinal preparations containing materials or reaction products thereof with undetermined constitution
12Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
48Reproductive organs
54Ovaries; Ova; Ovules; Embryos; Foetal cells; Germ cells
545Embryonic stem cells; Pluripotent stem cells; Induced pluripotent stem cells; Uncharacterised stem cells
A61K 35/76 2015.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
35Medicinal preparations containing materials or reaction products thereof with undetermined constitution
66Microorganisms or materials therefrom
76Viruses; Subviral particles; Bacteriophages
G01N 33/5
Applicants
  • CENTAGEN, INC [US]/[US]
Inventors
  • VILLEPONTEAU, Bryant
  • FOWLER, Carl
Agents
  • LAW, Aileen
Priority Data
62/828,28702.04.2019US
Publication Language English (EN)
Filing Language English (EN)
Designated States
Title
(EN) ENGINEERED SYSTEM OF STEM CELL REJUVENATION TO TREAT AGING AND DISEASE
(FR) SYSTÈME DE HAUTE TECHNOLOGIE DE RAJEUNISSEMENT DE CELLULES SOUCHES POUR TRAITER LE VIEILLISSEMENT ET LA MALADIE
Abstract
(EN)
The engineered system disclosed herein takes extracted adult stem cells from individual mammal organs (such as adipose fat, bone marrow, or blood) and epigenetically rejuvenates the adult stem cells ex vivo back to a youthful fetal state using chemically defined small molecules. The rejuvenated multipotent stem cells are then exponentially expanded ex vivo in an automated bioreactor under novel conditions that maintain the youthful stem cell function while greatly reducing the risks of producing cancer stem cells.
(FR)
Le système de haute technologie selon la présente invention utilise des cellules souches adultes extraites à partir d'organes de mammifère individuels (tels que la graisse adipeuse, la moelle osseuse ou le sang) et rajeunit génétiquement les cellules souches adultes ex vivo jusqu'à un état fœtal jeune en utilisant de petites molécules chimiquement définies. Les cellules souches multipotentes régénérées sont ensuite multipliées de manière exponentielle ex vivo dans un bioréacteur automatisé dans de nouvelles conditions qui maintiennent la fonction de cellule souche jeune tout en réduisant fortement les risques de production de cellules souches cancéreuses.
Latest bibliographic data on file with the International Bureau