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1. WO2020206050 - COMPOSITION TO SUPPORT HEALTHY BRAIN FUNCTION

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[ EN ]

CLAIMS

What is claimed is:

1. A composition comprising: (a) one or more bacteria having a nucleic acid sequence with at least 80% homology to the nucleic acid sequence of SEQ ID NO: 1; (b) a fermentate comprising a yeast; and (c) an excipient, carrier, and/or diluent.

2. The composition of Claim 1, wherein the one or more bacteria are selected from the group consisting of Clostridium sporogenes, Peptostreptococcus anaerobius, Clostridium cadaveris, Clostridium boltae , and combinations thereof.

3. The composition of Claim 1 or 2, wherein the fermentate further comprises one or more proteolytic enzymes.

4. The composition of any of the preceding claims, wherein the fermentate further comprises additional nutrients selected from the group consisting of carbohydrates, soy flour, and combinations thereof.

5. The composition of any of the preceding claims, wherein the fermentate further comprises at least one lactic acid bacteria or Bifidobacteria.

6. The composition of Claim 5, wherein the lactic acid bacteria or Bifidobacteria is selected from the group consisting of Lactobacillus acidophilus , Bifidobacterium bifidum ,

Lactobacillus rhamnosus, and mixtures thereof.

7. The composition of any of the preceding claims, wherein the composition comprises lxE3 to lxEl 1 colony-forming units (CFU) of the one or more bacteria.

8. The composition of any of the preceding claims, wherein the composition comprises from 1 mg to 2 g of the fermentate.

9. The composition of any of the preceding claims, wherein the one or more bacteria produce at least 5 pg/mL of indole-3 -propionic acid (IP A) after 24 hours of anaerobic in vitro incubation at 36°C with the fermentate.

10. The composition of any of the preceding claims, wherein the composition further comprises an active ingredient.

11. The composition of any of the preceding claims, wherein the composition further comprises an herbal ingredient.

12. The composition of any of the preceding claims, wherein the composition is a probiotic composition.

13. The composition of any of the preceding claims, wherein the one or more bacteria is

Clostridium sporogenes.

14. A method of promoting brain health comprising administering to an individual in need thereof the composition of Claim 1.

15. A method of delivering antioxidant nutrients to the brain comprising administering to an individual in need thereof the composition of Claim 1.