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1. WO2020205890 - EUKARYOTIC HOST SYSTEM FOR PRODUCING RECOMBINANT PROTEINS

Publication Number WO/2020/205890
Publication Date 08.10.2020
International Application No. PCT/US2020/026010
International Filing Date 31.03.2020
IPC
C07K 14/37 2006.01
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
14Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
37from fungi
C12N 15/79 2006.01
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
15Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
09Recombinant DNA-technology
63Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
79Vectors or expression systems specially adapted for eukaryotic hosts
C12N 15/80 2006.01
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
15Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
09Recombinant DNA-technology
63Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
79Vectors or expression systems specially adapted for eukaryotic hosts
80for fungi
C12P 21/00 2006.01
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
PFERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
21Preparation of peptides or proteins
Applicants
  • BEHR, Connor, David [US]/[US]
Inventors
  • BEHR, Connor, David
Agents
  • CAMPOLONGO, Michael J.
Priority Data
62/827,68501.04.2019US
Publication Language English (EN)
Filing Language English (EN)
Designated States
Title
(EN) EUKARYOTIC HOST SYSTEM FOR PRODUCING RECOMBINANT PROTEINS
(FR) SYSTÈME HÔTE EUCARYOTE POUR LA PRODUCTION DE PROTÉINES RECOMBINÉES
Abstract
(EN)
Disclosed herein are eukaryotic host systems for producing recombinant proteins, eukaryotic hosts modified to produce recombinant proteins, and methods of producing recombinant proteins using the same. In certain embodiments, the eukaryotic host system is a plasmodium of the class Myxogastria, such as Physarum polycephalum, modified to produce one or more recombinant proteins, such as human insulin. In certain embodiments, a method of protein production includes collecting one or more recombinant proteins produced by Physarum polycephalum while in a form of multinucleate plasmodia.
(FR)
L'invention concerne des systèmes hôtes eucaryotes pour la production de protéines recombinées, des hôtes eucaryotes modifiés pour produire des protéines recombinées et des procédés de production de protéines recombinées à l'aide de ceux-ci. Dans certains modes de réalisation, le système hôte eucaryote est un plasmodium de la classe des myxomycètes, tel que Physarum polycephalum, modifié pour produire une ou plusieurs protéines recombinées, telles que l'insuline humaine. Dans certains modes de réalisation, la présente invention concerne un procédé de production de protéines qui comprend la collecte d'une ou plusieurs protéines recombinées produites par Physarum polycephalum se présentant alors sous la forme d'un plasmodium multinucléé.
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