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1. WO2020205720 - MIXED-CELL GENE THERAPY

Publication Number WO/2020/205720
Publication Date 08.10.2020
International Application No. PCT/US2020/025689
International Filing Date 30.03.2020
IPC
A61L 27/38 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
LMETHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION, OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS, OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS, OR SURGICAL ARTICLES
27Materials for prostheses or for coating prostheses
36containing ingredients of undetermined constitution or reaction products thereof
38Animal cells
C12N 15/86 2006.01
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
15Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
09Recombinant DNA-technology
63Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
79Vectors or expression systems specially adapted for eukaryotic hosts
85for animal cells
86Viral vectors
C12N 15/63 2006.01
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
15Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
09Recombinant DNA-technology
63Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
Applicants
  • KOLON TISSUEGENE, INC. [US]/[US]
Inventors
  • NOH, Moon, Jong
  • YI, Youngsuk
  • SONG, Sun, Uk
  • LEE, Kwan, Hee
Agents
  • KIM, Joseph, Hypsuk
Priority Data
62/826,55329.03.2019US
Publication Language English (EN)
Filing Language English (EN)
Designated States
Title
(EN) MIXED-CELL GENE THERAPY
(FR) THÉRAPIE GÉNIQUE À CELLULES MIXTES
Abstract
(EN)
The subject invention is directed to a mixed cell composition to generate a therapeutic protein at a target site by providing a first population of mammalian cells transfected or transduced with a gene that is sought to be expressed, and a second population of mammalian cells that have not been transfected or transduced with the gene, wherein endogenously existing forms of the second population of mammalian cells are decreased at the target site, and wherein generation of the therapeutic protein by the first population of mammalian cells at the target site stimulates the second population cells to induce a therapeutic effect.
(FR)
La présente invention concerne une composition à cellules mixtes pour générer une protéine thérapeutique au niveau d'un site cible en fournissant une première population de cellules de mammifères transfectées ou transduites avec un gène dont l'expression est recherchée, et une seconde population de cellules de mammifères qui n'ont pas été transfectées ou transduites avec le gène, les formes présentes de manière endogène de la seconde population de cellules de mammifères étant diminuées au niveau du site cible, et la génération de la protéine thérapeutique par la première population de cellules de mammifères au niveau du site cible stimulant les cellules de la seconde population pour induire un effet thérapeutique.
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