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1. WO2020205560 - SULFONYLAMIDE COMPOUNDS AS CDK2 INHIBITORS

Publication Number WO/2020/205560
Publication Date 08.10.2020
International Application No. PCT/US2020/025335
International Filing Date 27.03.2020
IPC
A61P 35/00 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
35Antineoplastic agents
C07D 487/04 2006.01
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
487Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/-C07D477/183
02in which the condensed system contains two hetero rings
04Ortho-condensed systems
A61K 31/519 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
33Heterocyclic compounds
395having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
495having six-membered rings with two nitrogen atoms as the only ring hetero atoms, e.g. piperazine
505Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
519ortho- or peri-condensed with heterocyclic rings
CPC
A61P 35/00
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
35Antineoplastic agents
C07D 487/04
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
487Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by C07D451/00 - C07D477/00
02in which the condensed system contains two hetero rings
04Ortho-condensed systems
Applicants
  • INCYTE CORPORATION [US]/[US]
  • YE, Min [US]/[US]
  • CHEN, Yingnan [US]/[US]
  • FAVATA, Margaret [GB]/[US]
  • LO, Yvonne [US]/[US]
Inventors
  • YE, Min
  • CHEN, Yingnan
  • FAVATA, Margaret
  • LO, Yvonne
  • SOKOLSKY, Alexander
  • WINTERTON, Sarah
  • WU, Liangxing
  • YAO, Wenqing
Agents
  • CULHANE, Crystal L.
  • GODDARD, Christine A.
Priority Data
62/826,47729.03.2019US
Publication Language English (EN)
Filing Language English (EN)
Designated States
Title
(EN) SULFONYLAMIDE COMPOUNDS AS CDK2 INHIBITORS
(FR) COMPOSÉS SULFONYLAMIDES UTILISÉS COMME INHIBITEURS DE LA CDK2
Abstract
(EN)
The present application provides sulfonyl amide compounds of formula (I), which are inhibitors of cyclin-dependent kinase 2 (CDK2), as well as pharmaceutical compositions thereof, and methods of treating cancer using the same.
(FR)
La présente invention concerne des composés sulfonyl-amides représentés par la formule (I), qui sont des inhibiteurs de la kinase 2 dépendante des cyclines (CDK2), ainsi que des compositions pharmaceutiques de ceux-ci, et des procédés de traitement du cancer faisant appel à ceux-ci.
Latest bibliographic data on file with the International Bureau