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1. WO2020205204 - METHODS FOR THE DETECTION OF PROSTATE CANCER

Publication Number WO/2020/205204
Publication Date 08.10.2020
International Application No. PCT/US2020/022555
International Filing Date 13.03.2020
IPC
G01N 33/574 2006.01
GPHYSICS
01MEASURING; TESTING
NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
33Investigating or analysing materials by specific methods not covered by groups G01N1/-G01N31/131
48Biological material, e.g. blood, urine; Haemocytometers
50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
53Immunoassay; Biospecific binding assay; Materials therefor
574for cancer
CPC
G01N 33/57434
GPHYSICS
01MEASURING; TESTING
NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
33Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
48Biological material, e.g. blood, urine
50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
53Immunoassay; Biospecific binding assay; Materials therefor
574for cancer
57407Specifically defined cancers
57434of prostate
G01N 33/57488
GPHYSICS
01MEASURING; TESTING
NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
33Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
48Biological material, e.g. blood, urine
50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
53Immunoassay; Biospecific binding assay; Materials therefor
574for cancer
57484involving compounds serving as markers for tumor, cancer, neoplasia, e.g. cellular determinants, receptors, heat shock/stress proteins, A-protein, oligosaccharides, metabolites
57488involving compounds identifable in body fluids
Applicants
  • OPKO DIAGNOSTICS, LLC [US]/[US]
Inventors
  • OKRONGLY, David
Agents
  • BROWDER,, Monte R.
Priority Data
62/828,93503.04.2019US
Publication Language English (EN)
Filing Language English (EN)
Designated States
Title
(EN) METHODS FOR THE DETECTION OF PROSTATE CANCER
(FR) MÉTHODES DE DÉTECTION DU CANCER DE LA PROSTATE
Abstract
(EN)
Aspects of the disclosure relate to methods and systems for detecting prostate cancer and/or evaluating a subject for a prostate biopsy. In some embodiments, a subject may undergo an assessment to determine the likelihood of prostate cancer. For instance, one or more immunoassay may be performed on a blood sample of the subject to determine biomarker levels that may be used with certain clinical factors to determine a likelihood score for aggressive prostate cancer. A subject having a likelihood score within a threshold range may undergo a second assessment to determine the likelihood of prostate cancer. For example, the subject may undergo an imaging technique to detect prostate cancer. The outcome of the second assessment may be used to determine the likelihood of aggressive prostate cancer and/or biopsy recommendation. Methods and systems, described herein, may be particularly well-suited for the minimally invasive and cost-effective detection of prostate cancer in subjects.
(FR)
Certains aspects de l'invention concernent des méthodes et des systèmes pour détecter un cancer de la prostate et/ou évaluer un sujet pour une biopsie de la prostate. Dans certains modes de réalisation, un sujet peut subir une évaluation pour déterminer la probabilité de cancer de la prostate. Par exemple, un ou plusieurs dosages immunologiques peuvent être effectués sur un échantillon de sang du sujet pour déterminer des taux de biomarqueurs qui peuvent être utilisés avec certains facteurs cliniques pour déterminer un score de probabilité pour un cancer agressif de la prostate. Un sujet ayant un score de probabilité dans une plage de seuil peut subir une seconde évaluation pour déterminer la probabilité de cancer de la prostate. Par exemple, le sujet peut subir une technique d'imagerie pour détecter un cancer de la prostate. Le résultat de la seconde évaluation peut être utilisé pour déterminer la probabilité d'un cancer agressif de la prostate et/ou une recommandation de biopsie. Les méthodes et les systèmes selon l'invention peuvent être particulièrement bien adaptés à la détection invasive au minimum et rentable du cancer de la prostate chez des sujets.
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