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1. WO2020205100 - RECOMBINANT ERIL-15 NK CELLS

Publication Number WO/2020/205100
Publication Date 08.10.2020
International Application No. PCT/US2020/019991
International Filing Date 27.02.2020
IPC
C12N 5/0783 2010.01
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
5Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
07Animal cells or tissues
071Vertebrate cells or tissues, e.g. human cells or tissues
078Cells from blood or from the immune system
0783T cells; NK cells; Progenitors of T or NK cells
C07K 14/54 2006.01
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
14Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
435from animals; from humans
52Cytokines; Lymphokines; Interferons
54Interleukins (IL)
C07K 14/735 2006.01
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
14Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
435from animals; from humans
705Receptors; Cell surface antigens; Cell surface determinants
735Fc receptors
C07K 14/705 2006.01
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
14Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
435from animals; from humans
705Receptors; Cell surface antigens; Cell surface determinants
A61K 35/17
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
35Medicinal preparations containing materials or reaction products thereof with undetermined constitution
12Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
14Blood; Artificial blood
17Lymphocytes; B-cells; T-cells; Natural killer cells; Interferon-activated or cytokine-activated lymphocytes
A61P 35/00 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
35Antineoplastic agents
Applicants
  • NANTCELL, INC. [US]/[US]
  • NANTBIO, INC. [US]/[US]
  • NANTKWEST, INC. [US]/[US]
Inventors
  • SOON-SHIONG, Patrick
  • RABIZADEH, Shahrooz
  • NIAZI, Kayvan
  • KLINGEMANN, Hans
Agents
  • FESSENMAIER, Martin
  • PHUKAN, Priti D.
  • DEAN, Ryan
  • BALLEW CHANG, Nicole
Priority Data
62/819,25615.03.2019US
Publication Language English (EN)
Filing Language English (EN)
Designated States
Title
(EN) RECOMBINANT ERIL-15 NK CELLS
(FR) CELLULES NK ERIL-15 RECOMBINANTES
Abstract
(EN)
Systems and methods are presented that provide for improved NK cell function. In preferred aspects, NK-92 cells express recombinant er/LSP-IL-15 to so render the NK-92 cells independent of exogenous cytokines and to provide extracellular immune stimulation.
(FR)
L'invention concerne des systèmes et des procédés qui fournissent une fonction de cellule NK améliorée. Dans des aspects préférés, les cellules NK-92 expriment er/LSP-IL-15 recombinant pour rendre les cellules NK-92 indépendantes des cytokines exogènes et pour fournir une stimulation immunitaire extracellulaire.
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