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1. WO2020205034 - SIALIDASE-RESISTANT SACCHARIDE AND METHOD OF MAKING AND USING THE SAME

Publication Number WO/2020/205034
Publication Date 08.10.2020
International Application No. PCT/US2020/014608
International Filing Date 10.03.2020
IPC
C07H 1/00 2006.01
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
HSUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
1Processes for the preparation of sugar derivatives
C07H 3/02 2006.01
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
HSUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
3Compounds containing only hydrogen atoms and saccharide radicals having only carbon, hydrogen, and oxygen atoms
02Monosaccharides
C07K 16/30 2006.01
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
16Immunoglobulins, e.g. monoclonal or polyclonal antibodies
18against material from animals or humans
28against receptors, cell surface antigens or cell surface determinants
30from tumour cells
A61P 35/00 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
35Antineoplastic agents
A61K 39/00 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
39Medicinal preparations containing antigens or antibodies
Applicants
  • ACADEMIA SINICA
  • WONG, Chi-Huey
Inventors
  • WONG, Chi-Huey
  • LO, Hong-Jay
Agents
  • TSAO, Rocky Y.
Priority Data
62/829,73605.04.2019US
Publication Language English (EN)
Filing Language English (EN)
Designated States
Title
(EN) SIALIDASE-RESISTANT SACCHARIDE AND METHOD OF MAKING AND USING THE SAME
(FR) SACCHARIDE RÉSISTANT À LA SIALIDASE, SON PROCÉDÉ DE PRODUCTION ET SON UTILISATION
Abstract
(EN)
Disclosed are a method of preparing a saccharide that contains a 3-fluoro-sialic acid and a method of bonding it to a homogeneous antibody. Also within the scope of this invention are compounds each containing a 3-fluoro-sialic acid, monoclonal antibodies bonded to α2,6-linked 3-fluoro-sialoside terminated N-glycans, and treatment of cancer with such monoclonal antibodies.
(FR)
L'invention concerne un procédé de préparation d'un saccharide qui contient un acide 3-fluoro-sialique et un procédé de liaison de celui-ci à un anticorps homogène. L'invention concerne également des composés contenant chacun un acide 3-fluoro-sialique, des anticorps monoclonaux liés à un 3-fluoro-sialoside à extrémités N-glycanes à liaison en positions 2 et 6; l'invention concerne en outre le traitement du cancer à l'aide de tels anticorps monoclonaux.
Latest bibliographic data on file with the International Bureau