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1. WO2020204644 - COMPOSITION CONTAINING HEALTHY EXTRACT AS ACTIVE INGREDIENT FOR ENHANCING PRODUCTION RATES OF NEUTRALIZING ANTIBODIES

Publication Number WO/2020/204644
Publication Date 08.10.2020
International Application No. PCT/KR2020/004542
International Filing Date 03.04.2020
IPC
A23L 33/10 2016.01
AHUMAN NECESSITIES
23FOODS OR FOODSTUFFS; THEIR TREATMENT, NOT COVERED BY OTHER CLASSES
LFOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D91; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
33Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
10using additives
A61K 36/9068 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
36Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
18Magnoliophyta (angiosperms)
88Liliopsida (monocotyledons)
906Zingiberaceae (Ginger family)
9068Zingiber, e.g. garden ginger
A61K 39/39 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
39Medicinal preparations containing antigens or antibodies
39characterised by the immunostimulating additives, e.g. chemical adjuvants
A61P 31/12 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
31Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
12Antivirals
A61K 39/00 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
39Medicinal preparations containing antigens or antibodies
Applicants
  • 한국 한의학 연구원 KOREA INSTITUTE OF ORIENTAL MEDICINE [KR]/[KR]
Inventors
  • 유수성 YOU, Sooseong
  • 이호영 LEE, Hoyoung
  • 김지현 KIM, Jihyun
  • 심은형 SHIM, Eun Hyoung
Agents
  • 최규환 CHOI, Kyu Whan
Priority Data
10-2019-003963004.04.2019KR
Publication Language Korean (KO)
Filing Language Korean (KO)
Designated States
Title
(EN) COMPOSITION CONTAINING HEALTHY EXTRACT AS ACTIVE INGREDIENT FOR ENHANCING PRODUCTION RATES OF NEUTRALIZING ANTIBODIES
(FR) COMPOSITION CONTENANT UN EXTRAIT SAIN EN TANT QUE PRINCIPE ACTIF POUR AMÉLIORER LES TAUX DE PRODUCTION D'ANTICORPS NEUTRALISANTS
(KO) 건강 추출물을 유효성분으로 포함하는 중화항체 생성율 증진용 조성물
Abstract
(EN)
The present invention pertains to a composition for enhancing the production rates of neutralizing antibodies, the composition containing a healthy extract as an active ingredient. In an animal model inoculated with a vaccine after the administration of the healthy extract of the present invention, there are the effects in which the formation of antigen-specific antibodies is enhanced, the production rate of cytokine produced by antigen stimulation, which has been lowered by anticancer drugs, is restored, and the production rates of antibodies to H1N1 and H3N2 antigens are enhanced after vaccination. Thus, applying the composition of the present invention to immunocompromised patients or the elderly prior to flu vaccination is expected to increase the production rate of antibodies.
(FR)
La présente invention concerne une composition pour le taux de production d'anticorps neutralisants, la composition contenant un extrait saint en tant que principe actif. Dans un modèle animal inoculé avec un vaccin après l'administration de l'extrait sain de la présente invention, il existe des effets dans lesquels la formation d'anticorps spécifiques d'antigène est améliorée, le taux de production de cytokine produit par stimulation d'antigène, qui a été abaissé par des médicaments anticancéreux, est rétabli, et les taux de production d'anticorps contre les antigènes H1N1 et H3N2 sont améliorés après vaccination. Ainsi, l'application de la composition de la présente invention à des patients immunodéprimés ou aux personnes âgées avant la vaccination contre la grippe est attendue pour augmenter le taux de production d'anticorps.
(KO)
본 발명은 건강 추출물을 유효성분으로 포함하는 중화항체 생성율 증진용 조성물에 관한 것으로, 본 발명의 건강 추출물을 투여한 후, 백신을 접종한 동물모델은 항원 특이 항체 형성이 증진되었고, 항암제에 의해 저하되었던 항원 자극에 의해 생성되는 사이토카인의 생성 비율이 회복되며, 백신 접종 후, H1N1 및 H3N2 항원에 대한 항체 생성율이 증진되는 효과가 있으므로, 본 발명의 조성물을 독감백신 접종 전에 면역력인 낮아진 환자 또는 노인들에게 적용하면 항체 생성율을 증진시킬 수 있을 것으로 기대된다.
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