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1. WO2020203610 - USE OF T-TYPE CALCIUM CHANNEL BLOCKER FOR TREATING RHEUMATOID ARTHRITIS

Publication Number WO/2020/203610
Publication Date 08.10.2020
International Application No. PCT/JP2020/013543
International Filing Date 26.03.2020
IPC
A61P 19/02 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
19Drugs for skeletal disorders
02for joint disorders, e.g. arthritis, arthrosis
A61P 29/00 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
29Non-central analgesic, antipyretic or antiinflammatory agents, e.g antirheumatic agents; Non-steroidal antiinflammatory drugs (NSAIDs)
A61P 43/00 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
43Drugs for specific purposes, not provided for in groups A61P1/-A61P41/108
C07D 207/14 2006.01
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
207Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
02with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
04having no double bonds between ring members or between ring members and non-ring members
10with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
14Nitrogen atoms not forming part of a nitro radical
C07D 401/04 2006.01
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
401Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
02containing two hetero rings
04directly linked by a ring-member-to-ring- member bond
C07D 401/12 2006.01
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
401Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
02containing two hetero rings
12linked by a chain containing hetero atoms as chain links
Applicants
  • 日本ケミファ株式会社 NIPPON CHEMIPHAR CO., LTD. [JP]/[JP]
  • ユーティアイ リミテッド パートナーシップ UTI LIMITED PARTNERSHIP [CA]/[CA]
  • 学校法人近畿大学 KINKI UNIVERSITY [JP]/[JP]
Inventors
  • ゲラルド ダブリュ ザンポーニ Gerald W. Zamponi
  • ヴィニシウス デ マリア ガドッティ Vinicius de Maria Gadotti
  • 川畑 篤史 KAWABATA Atsufumi
  • 小川 亨 OGAWA Toru
  • 田中 博人 TANAKA Hiroto
  • 大井 勲 OOI Isao
  • 齊藤 大祐 SAITO Daisuke
  • 林田 康平 HAYASHIDA Kohei
  • 山元 広平 YAMAMOTO Kohei
Agents
  • 千草 新一 CHIGUSA Shinichi
  • 橋本 諭志 HASHIMOTO Satoshi
  • 砂原 一公 SUNAHARA Hisato
Priority Data
2019-06850529.03.2019JP
Publication Language Japanese (JA)
Filing Language Japanese (JA)
Designated States
Title
(EN) USE OF T-TYPE CALCIUM CHANNEL BLOCKER FOR TREATING RHEUMATOID ARTHRITIS
(FR) UTILISATION D'UN BLOQUEUR DES CANAUX CALCIQUES DE TYPE T SERVANT AU TRAITEMENT DE LA POLYARTHRITE RHUMATOÏDE
(JA) 関節リウマチを治療するためのT型カルシウムチャネル阻害剤の使用
Abstract
(EN)
Provided is a medicinal drug for treating or preventing rheumatoid arthritis. As a medicinal drug for treating or preventing rheumatoid arthritis, the present invention uses, as an active ingredient, a compound that has an effect of blocking the T-type calcium channel (Cav3.2 channel) and that is represented by any one of general formulae (I)-(VI), a tautomer, a stereoisomer, or a pharmaceutically acceptable salt of the compound, or a solvate thereof.
(FR)
L'invention concerne un produit médicinal servant au traitement ou à la prévention de la polyarthrite rhumatoïde. En tant que produit médicinal servant au traitement ou à la prévention de la polyarthrite rhumatoïde, la présente invention utilise, en tant que principe actif, un composé qui a pour effet de bloquer les canaux calciques de type T (canal Cav3.2) et qui est représenté par l'une quelconque des formules générales (I)- (VI), un tautomère, un stéréoisomère, ou un sel pharmaceutiquement acceptable du composé, ou un solvate de ce dernier.
(JA)
関節リウマチの治療又は予防のための医薬を提供する。 関節リウマチに対する治療又は予防のための医薬として、一般式(I)~(VI)で表されるT型カルシウムチャネル(Cav3.2チャネル)の阻害作用を有する化合物、該化合物の互変異性体、立体異性体、若しくはその薬学的に許容される塩又はそれらの溶媒和物を有効成分として用いる。
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