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1. WO2020202950 - INORGANIC POROUS CARRIER AND METHOD FOR PRODUCING NUCLEIC ACIDS USING SAME

Publication Number WO/2020/202950
Publication Date 08.10.2020
International Application No. PCT/JP2020/008318
International Filing Date 28.02.2020
IPC
B01J 31/26 2006.01
BPERFORMING OPERATIONS; TRANSPORTING
01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
JCHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
31Catalysts comprising hydrides, coordination complexes or organic compounds
26containing in addition, inorganic metal compounds not provided for in groups B01J31/02-B01J31/24129
B01J 32/00 2006.01
BPERFORMING OPERATIONS; TRANSPORTING
01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
JCHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
32Catalyst carriers in general
C01B 33/12 2006.01
CCHEMISTRY; METALLURGY
01INORGANIC CHEMISTRY
BNON-METALLIC ELEMENTS; COMPOUNDS THEREOF
33Silicon; Compounds thereof
113Silicon oxides; Hydrates thereof
12Silica; Hydrates thereof, e.g. lepidoic silicic acid
C01B 39/02 2006.01
CCHEMISTRY; METALLURGY
01INORGANIC CHEMISTRY
BNON-METALLIC ELEMENTS; COMPOUNDS THEREOF
39Compounds having molecular sieve and base-exchange properties, e.g. crystalline zeolites; Their preparation; After-treatment, e.g. ion-exchange or dealumination
02Crystalline aluminosilicate zeolites; Isomorphous compounds thereof; Direct preparation thereof; Preparation thereof starting from a reaction mixture containing a crystalline zeolite of another type, or from preformed reactants; After-treatment thereof
C01B 39/36 2006.01
CCHEMISTRY; METALLURGY
01INORGANIC CHEMISTRY
BNON-METALLIC ELEMENTS; COMPOUNDS THEREOF
39Compounds having molecular sieve and base-exchange properties, e.g. crystalline zeolites; Their preparation; After-treatment, e.g. ion-exchange or dealumination
02Crystalline aluminosilicate zeolites; Isomorphous compounds thereof; Direct preparation thereof; Preparation thereof starting from a reaction mixture containing a crystalline zeolite of another type, or from preformed reactants; After-treatment thereof
36Pentasil type, e.g. types ZSM-5, ZSM-8 or ZSM-11
C07H 21/02 2006.01
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
HSUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
21Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
02with ribosyl as saccharide radical
Applicants
  • 住友化学株式会社 SUMITOMO CHEMICAL COMPANY, LIMITED [JP]/[JP]
Inventors
  • 山▲崎▼ 香菜子 YAMAZAKI, Kanako
  • 北原 真樹 KITAHARA, Masaki
  • 原 孝志 HARA, Takashi
  • 吉岡 健 YOSHIOKA, Takeshi
Agents
  • 山尾 憲人 YAMAO, Norihito
  • 森本 靖 MORIMOTO, Yasushi
Priority Data
2019-06799429.03.2019JP
Publication Language Japanese (JA)
Filing Language Japanese (JA)
Designated States
Title
(EN) INORGANIC POROUS CARRIER AND METHOD FOR PRODUCING NUCLEIC ACIDS USING SAME
(FR) SUPPORT POREUX INORGANIQUE ET PROCÉDÉ DE PRODUCTION D'ACIDES NUCLÉIQUES L'UTILISANT
(JA) 無機多孔質担体及びこれを用いた核酸の製造方法
Abstract
(EN)
The present invention provides: an inorganic porous carrier, which can increase yield, etc., in the production of nucleic acids, has pore distribution in which a pore diameter (mode diameter) is 0.04 μm or more, and has a linker represented by formula (1) [in the formula, * represents a bond of a silanol group of an inorganic porous body to an oxygen group. R1 and R2 represent a C3-C10 alkyl group or phenyl group. L represents a single bond, a C1-C20 alkylene group, or a C2-C20 alkylene group which includes -CH2-Q-CH2- that is a group in which Q selected from the group consisting of -O-, -NH-, -NH-CO-, and -NH-CO-NH- is inserted to at least one -CH2-CH2- group constituting said alkylene group. The carbon atom of the methylene group bonding with the group Q does not bond with a separate group Q at the same time.]; and a method for producing nucleic acids using the same.
(FR)
La présente invention concerne : un support poreux inorganique, qui peut augmenter le rendement, etc. dans la production d'acides nucléiques, a une distribution de pores dans laquelle un diamètre de pore (diamètre de mode) est de 0,04 µm ou plus, et a un lieur représenté par la formule (1) [dans la formule, * représente une liaison d'un groupe silanol d'un corps poreux inorganique à un groupe oxygène. R1 et R2 représentent un groupe alkyle en C3-C10 ou un groupe phényle. L représente une liaison simple, un groupe alkylène en C1-C20, ou un groupe alkylène en C2-C20 qui comprend - CH2-Q-CH2 - qui est un groupe dans lequel Q est choisi dans le groupe constitué par -O-, -NH-, -NH-CO-, et -NH-CO-NH- est inséré dans au moins un groupe -CH2-CH2- constituant ledit groupe alkylène. L'atome de carbone du groupe méthylène se liant avec le groupe Q ne se lie pas à un groupe séparé Q en même temps.] ; et un procédé de production d'acides nucléiques l'utilisant.
(JA)
本発明は、核酸の製造において収率等をより高められる、式(1)[式中、*は、無機多孔質体のシラノール基の酸素原子への結合を表す。R及びRは、炭素数3~10のアルキル基又はフェニル基を表す。Lは、単結合、炭素数1~20のアルキレン基、又は、炭素数2~20のアルキレン基であって当該アルキレン基を構成する少なくとも1つの-CH-CH-基に、-O-、-NH-、-NH-CO-及び-NH-CO-NH-からなる群から選ばれる基Qが挿入されている基:-CH-Q-CH-を含む基を表す。基Qと結合しているメチレン基の炭素原子は、さらに別の基Qと同時に結合することはない。]、で表されるリンカーを有し、細孔径(モード径)が0.04μm以上の細孔分布を有する無機多孔質担体、及びこれを用いた核酸の製造方法を提供する。
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