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1. WO2020201444 - REPURPOSING SMALL MOLECULES FOR SENESCENCE-RELATED DISEASES AND DISORDERS

Publication Number WO/2020/201444
Publication Date 08.10.2020
International Application No. PCT/EP2020/059436
International Filing Date 02.04.2020
IPC
A61K 31/015 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
01Hydrocarbons
015carbocyclic
A61P 27/02 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
27Drugs for disorders of the senses
02Ophthalmic agents
A61P 17/00 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
17Drugs for dermatological disorders
A61P 9/00 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
9Drugs for disorders of the cardiovascular system
A61K 31/472 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
33Heterocyclic compounds
395having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
435having six-membered rings with one nitrogen as the only ring hetero atom
47Quinolines; Isoquinolines
472Non-condensed isoquinolines, e.g. papaverine
CPC
A61K 31/015
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
01Hydrocarbons
015carbocyclic
A61K 31/472
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
33Heterocyclic compounds
395having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
435having six-membered rings with one nitrogen as the only ring hetero atom
47Quinolines; Isoquinolines
472Non-condensed isoquinolines, e.g. papaverine
A61P 17/00
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
17Drugs for dermatological disorders
A61P 27/02
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
27Drugs for disorders of the senses
02Ophthalmic agents
A61P 9/00
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
9Drugs for disorders of the cardiovascular system
Applicants
  • ETERNANS LTD [GB]/[GB]
Inventors
  • ÇINAROGLU, Süleyman, Selim
  • TIMUCIN, Emel
  • SEZERMAN, Ugar
  • AKCAPINAR, Gunseli, Bayram
  • AHISKA, Yavuz
Agents
  • PAULRAJ, Leonita
Priority Data
62/828,23002.04.2019US
Publication Language English (EN)
Filing Language English (EN)
Designated States
Title
(EN) REPURPOSING SMALL MOLECULES FOR SENESCENCE-RELATED DISEASES AND DISORDERS
(FR) MODIFICATION DES INDICATIONS DE PETITES MOLÉCULES POUR DES MALADIES ET DES TROUBLES LIÉS À LA SÉNESCENCE
Abstract
(EN)
Provided herein are methods of use of 12 small molecules extracted from ZINC15 library for treating senescence-associated diseases and disorders by specifically targeting the FoxO4 protein. The diseases and disorders treatable with said repurposed Senolytic Agents include diseases with inflammatory origin including but not restricted to diabetes, cardiovascular diseases, or pulmonary diseases, including COPD; asthma, emphysema, or breathlessness; renal or hepatic insufficiency, cirrhosis, or osteoarthritis; senescence-associated ophthalmic diseases and disorders; and senescence-associated dermatological diseases and disorders; diabetic ulcers; kyphosis; scoliosis; weight loss; hair loss; muscle loss; loss of bone density; frailty and/or reduced fitness; hearing loss such as deafness; or combinations thereof.
(FR)
L'invention concerne des procédés d'utilisation de 12 petites molécules extraites de la bibliothèque ZINC15 pour traiter des maladies et des troubles associés à la sénescence par ciblage spécifique de la protéine FoxO4. Les agents sénolytiques aux indications modifiées fournis par la présente invention permettent de traiter des maladies et des troubles dont toutes les maladies ayant une origine inflammatoire comprenant, mais sans caractère limitatif, le diabète, les maladies cardiovasculaires, les maladies pulmonaires, y compris la BPCO ; l'asthme, l'emphysème ou la dyspnée ; l'insuffisance rénale ou hépatique, la cirrhose ou l'arthrose ; des maladies et des troubles ophtalmiques associés à la sénescence ; et des maladies et des troubles dermatologiques associés à la sénescence ; des ulcères diabétiques ; une cyphose ; une scoliose ; une perte de poids ; une perte de cheveux ; une perte musculaire ; une perte de densité osseuse ; une fragilité et/ou une forme physique réduite ; une perte auditive telle qu'une surdité ; ou des combinaisons associées.
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