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1. WO2020200460 - METHOD TO PACKAGE A TISSUE MATRIX TO BE REGENERATED

Publication Number WO/2020/200460
Publication Date 08.10.2020
International Application No. PCT/EP2019/058538
International Filing Date 04.04.2019
IPC
A01N 1/02 2006.01
AHUMAN NECESSITIES
01AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
NPRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
1Preservation of bodies of humans or animals, or parts thereof
02Preservation of living parts
A61L 27/36 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
LMETHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION, OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS, OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS, OR SURGICAL ARTICLES
27Materials for prostheses or for coating prostheses
36containing ingredients of undetermined constitution or reaction products thereof
CPC
A01N 1/0242
AHUMAN NECESSITIES
01AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
NPRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES, AS HERBICIDES
1Preservation of bodies of humans or animals, or parts thereof
02Preservation of living parts
0236Mechanical aspects
0242Apparatuses, i.e. devices used in the process of preservation of living parts, such as pumps, refrigeration devices or any other devices featuring moving parts and/or temperature controlling components
A01N 1/0263
AHUMAN NECESSITIES
01AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
NPRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES, AS HERBICIDES
1Preservation of bodies of humans or animals, or parts thereof
02Preservation of living parts
0236Mechanical aspects
0263Non-refrigerated containers specially adapted for transporting or storing living parts whilst preserving, e.g. cool boxes, blood bags or "straws" for cryopreservation
A01N 1/0289
AHUMAN NECESSITIES
01AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
NPRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES, AS HERBICIDES
1Preservation of bodies of humans or animals, or parts thereof
02Preservation of living parts
0278Physical preservation processes
0289Pressure processes, i.e. using a designated change in pressure over time
A61L 27/3691
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
LMETHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION, OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS, OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS, OR SURGICAL ARTICLES
27Materials for ; grafts or; prostheses or for coating ; grafts or; prostheses
36containing ingredients of undetermined constitution or reaction products thereof ; , e.g. transplant tissue, natural bone, extracellular matrix
3683subjected to a specific treatment prior to implantation, e.g. decellularising, demineralising, grinding, cellular disruption/non-collagenous protein removal, anti-calcification, crosslinking, supercritical fluid extraction, enzyme treatment
3691characterised by physical conditions of the treatment, e.g. applying a compressive force to the composition, pressure cycles, ultrasonic/sonication or microwave treatment, lyophilisation
Applicants
  • THERACELL CONSULTING SPRL [BE]/[BE]
Inventors
  • DUFRANE, Denis
Agents
  • KIRKPATRICK
Priority Data
Publication Language English (EN)
Filing Language English (EN)
Designated States
Title
(EN) METHOD TO PACKAGE A TISSUE MATRIX TO BE REGENERATED
(FR) PROCÉDÉ DE CONDITIONNEMENT D'UNE MATRICE TISSULAIRE À RÉGÉNÉRER
Abstract
(EN)
The invention relates to the field of packaging a biological tissue to be regenerated before grafting. A method for producing a vial (2), under vacuum, comprising a biological tissue matrix (10), comprises the steps of: placing a treated ex-vivo tissue sample in an open rigid vial; placing the vial in a lyophilizer; running a lyophilization process under vacuum to convert the treated ex-vivo tissue sample into a biological tissue matrix; hermetically sealing the vial with closing means, inside the lyophilizer under vacuum, and removing the sealed vial from the lyophilizer. Because the tissue matrix is not exposed to ambient air after lyophilization, the humidity content of the packaged material remains below 10% by weight and preferably below 6% by weight, allowing a longer shelf-life. A method to regenerate the biological tissue matrix packaged in the vial sealed under vacuum is also disclosed, which comprises introducing in the vial a regenerating fluid (21). This can be performed through the use of a syringe (20).
(FR)
L'invention appartient au domaine du conditionnement d'un tissu biologique à régénérer avant greffage. Un procédé de production d'un flacon (2), sous vide, comprenant une matrice de tissu biologique (10), comprend les étapes consistant à : placer un échantillon de tissu ex vivo traité dans un flacon rigide ouvert ; placer le flacon dans un lyophilisateur ; exécuter un processus de lyophilisation sous vide pour transformer l'échantillon de tissu ex vivo traité en une matrice de tissu biologique ; fermer hermétiquement le flacon avec des moyens de fermeture, à l'intérieur du lyophilisateur sous vide, et retirer le flacon fermé hermétiquement du lyophilisateur. Du fait que la matrice tissulaire n’est pas exposée à l'air ambiant après lyophilisation, la teneur en humidité du matériau conditionné reste inférieure à 10 % en poids et de préférence inférieure à 6 % en poids, ce qui permet une durée de conservation plus longue. L'invention concerne également un procédé de régénération de la matrice de tissu biologique conditionnée dans le flacon fermé hermétiquement sous vide, qui comprend l'introduction dans le flacon d'un fluide de régénération (21). Ceci peut être réalisé grâce à l'utilisation d'une seringue (20).
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