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1. WO2020200314 - NITROGEN-CONTAINING SPIRO DERIVATIVE AS RET INHIBITOR

Publication Number WO/2020/200314
Publication Date 08.10.2020
International Application No. PCT/CN2020/083255
International Filing Date 03.04.2020
IPC
C07D 471/10 2006.01
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
471Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/-C07D463/251
02in which the condensed system contains two hetero rings
10Spiro-condensed systems
C07D 401/14 2006.01
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
401Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
14containing three or more hetero rings
C07D 403/14 2006.01
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
403Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/167
14containing three or more hetero rings
A61K 31/506 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
33Heterocyclic compounds
395having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
495having six-membered rings with two nitrogen atoms as the only ring hetero atoms, e.g. piperazine
505Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
506not condensed and containing further heterocyclic rings
A61P 35/00 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
35Antineoplastic agents
Applicants
  • 南京明德新药研发有限公司 MEDSHINE DISCOVERY INC. [CN]/[CN]
Inventors
  • 付志飞 FU, Zhifei
  • 罗妙荣 LUO, Miaorong
  • 张杨 ZHANG, Yang
  • 蔡亚磊 CAI, Yalei
  • 朱武 ZHU, Wu
  • 黎健 LI, Jian
  • 陈曙辉 CHEN, Shuhui
Agents
  • 上海弼兴律师事务所 SHANGHAI BESHINING LAW OFFICE
Priority Data
201910270287.203.04.2019CN
201910937884.629.09.2019CN
201910980684.915.10.2019CN
202010199443.319.03.2020CN
Publication Language Chinese (ZH)
Filing Language Chinese (ZH)
Designated States
Title
(EN) NITROGEN-CONTAINING SPIRO DERIVATIVE AS RET INHIBITOR
(FR) DÉRIVÉ SPIRO CONTENANT DE L'AZOTE UTILISÉ EN TANT QU'INHIBITEUR DE RET
(ZH) 作为RET抑制剂的含氮螺环衍生物
Abstract
(EN)
Disclosed are a series of compounds with a nitrogen-containing spiro structure and an application thereof in the preparation of an RET kinase inhibitor. Specifically, disclosed is a compound as shown in formula (II) or a pharmaceutically acceptable salt thereof.
(FR)
L'invention concerne une série de composés ayant une structure spiro contenant de l'azote et une application de ceux-ci dans la préparation d'un inhibiteur de kinase RET. De façon spécifique, l'invention concerne un composé tel que présenté dans la formule (II) ou un sel pharmaceutiquement acceptable de celui-ci.
(ZH)
公开了一系列带有含氮螺环结构的化合物,及其在制备RET激酶抑制剂中的应用。具体公开了式(II)所示化合物或其药学上可接受的盐。
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