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1. WO2020200284 - PREPARATION METHOD FOR TRICYCLIC COMPOUND AND USE OF SAME IN FIELD OF MEDICINE

Publication Number WO/2020/200284
Publication Date 08.10.2020
International Application No. PCT/CN2020/083004
International Filing Date 02.04.2020
IPC
C07D 471/04 2006.01
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
471Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/-C07D463/251
02in which the condensed system contains two hetero rings
04Ortho-condensed systems
C07D 471/14 2006.01
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
471Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/-C07D463/251
12in which the condensed system contains three hetero rings
14Ortho-condensed systems
C07D 413/04 2006.01
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
413Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
02containing two hetero rings
04directly linked by a ring-member-to-ring- member bond
C07D 413/14 2006.01
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
413Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
14containing three or more hetero rings
C07D 417/14 2006.01
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
417Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/196
14containing three or more hetero rings
C07D 513/04 2006.01
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
513Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/, C07D477/232
02in which the condensed system contains two hetero rings
04Ortho-condensed systems
Applicants
  • 上海华汇拓医药科技有限公司 SHANGHAI SYNERGY PHARMACEUTICAL SCIENCES CO., LTD. [CN]/[CN]
  • 浙江华海药业股份有限公司 ZHEJIANG HUAHAI PHARMACEUTICAL CO., LTD. [CN]/[CN]
Inventors
  • 张瑱 ZHANG, Zhen
  • 许忻 XU, Xin
  • 李云飞 LI, Yunfei
  • 武琦梅 WU, Qimei
  • 张立明 ZHANG, Liming
  • 王影 WANG, Ying
  • 覃华 QIN, Hua
  • 杨旭芹 YANG, Xuqin
  • 李东升 LI, Dongsheng
  • 刘磊 LIU, Lei
  • 臧成旭 ZANG, Chengxu
  • 苏晶 SU, Jing
  • 秦成刚 QIN, Chenggang
  • 段飞飞 DUAN, Feifei
  • 王艺瑾 WANG, Yijin
  • 葛建 GE, Jian
Agents
  • 北京柏杉松知识产权代理事务所(普通合伙) PATENTSINO IP FIRM
Priority Data
201910271014.X04.04.2019CN
Publication Language Chinese (ZH)
Filing Language Chinese (ZH)
Designated States
Title
(EN) PREPARATION METHOD FOR TRICYCLIC COMPOUND AND USE OF SAME IN FIELD OF MEDICINE
(FR) PROCÉDÉ DE PRÉPARATION DE COMPOSÉ TRICYCLIQUE ET SON UTILISATION DANS LE DOMAINE DE LA MÉDECINE
(ZH) 三环类化合物制备方法及其在医药领域的应用
Abstract
(EN)
Provided are a tricyclic small molecule compound, a preparation method therefor, a pharmaceutical composition containing said compound, and use thereof in medicine. Said compound is used as a bromodomain protein 4 (BRD4) inhibitor, and can be used for preventing and/or treating diseases related to BRD4, such as malignant tumors.
(FR)
L'invention concerne un composé tricyclique à petites molécules, son procédé de préparation, une composition pharmaceutique contenant ledit composé et son utilisation en médecine. Ledit composé est utilisé en tant qu'inhibiteur de protéine à bromodomaine 4 (BRD4), et peut être utilisé pour prévenir et/ou traiter des maladies associées à BRD4, telles que des tumeurs malignes.
(ZH)
提供了一种三环类小分子化合物、其制备方法及含有该化合物的药物组合物,及其在医药方面的应用。所述化合物作为溴结构域蛋白4(BRD4)抑制剂,可用于预防和/或治疗与BRD4相关的疾病,如恶性肿瘤等。
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