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1. WO2020200160 - QUINOLYL-CONTAINING COMPOUND AND PHARMACEUTICAL COMPOSITION, AND USE THEREOF

Publication Number WO/2020/200160
Publication Date 08.10.2020
International Application No. PCT/CN2020/082041
International Filing Date 30.03.2020
IPC
C07D 215/233 2006.01
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
215Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
02having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
16with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
20Oxygen atoms
22attached in position 2 or 4
233only one oxygen atom which is attached in position 4
C07D 401/12 2006.01
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
401Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
02containing two hetero rings
12linked by a chain containing hetero atoms as chain links
A61K 31/4709 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
33Heterocyclic compounds
395having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
435having six-membered rings with one nitrogen as the only ring hetero atom
47Quinolines; Isoquinolines
4709Non-condensed quinolines containing further heterocyclic rings
A61K 31/47 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
33Heterocyclic compounds
395having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
435having six-membered rings with one nitrogen as the only ring hetero atom
47Quinolines; Isoquinolines
A61P 17/06 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
17Drugs for dermatological disorders
06Antipsoriatics
A61P 1/16 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
1Drugs for disorders of the alimentary tract or the digestive system
16for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
Applicants
  • 北京国鸿生物医药科技有限公司 BEIJING GUOHONG BIOMEDICAL TECHNOLOGY CO., LTD. [CN]/[CN]
Inventors
  • 吴伟 WU, Wei
  • 祝力 ZHU, Li
  • 杨艳青 YANG, Yanqing
  • 胡伟 HU, Wei
  • 张慧 ZHANG, Hui
  • 董长新 DONG, Changxin
Agents
  • 北京律智知识产权代理有限公司 BEIJING INTELLEGAL INTELLECTUAL PROPERTY AGENT LTD.
Priority Data
201910266681.903.04.2019CN
Publication Language Chinese (ZH)
Filing Language Chinese (ZH)
Designated States
Title
(EN) QUINOLYL-CONTAINING COMPOUND AND PHARMACEUTICAL COMPOSITION, AND USE THEREOF
(FR) COMPOSÉ CONTENANT DU QUINOLYLE, COMPOSITION PHARMACEUTIQUE ET UTILISATION ASSOCIÉE
(ZH) 一种含喹啉基化合物、药物组合物以及其用途
Abstract
(EN)
Provided is a quinolyl-containing compound as shown in general formula (I) or (II) or a pharmaceutically acceptable salt, a solvate, an active metabolite, a polymorph, an isotopic label, or an isomer thereof, and further provided are a pharmaceutical composition comprising the compound and use of the compound and the pharmaceutical composition. The provided compound has a dual molecule function, can serve as multi-target inhibitors of novel tyrosine kinase/histone deacetylase, can simultaneously achieve the effect of two inhibitors, has excellent biological activity and pharmacokinetic properties, and has the application potential particularly in the field of treatment of tumors.
(FR)
L'invention concerne un composé contenant du quinolyle tel que représenté dans la formule générale (I) ou (II) ou un sel pharmaceutiquement acceptable, un solvate, un métabolite actif, un polymorphe, une étiquette isotopique, ou un isomère correspondant. L'invention concerne en outre une composition pharmaceutique comprenant le composé et l'utilisation du composé et de la composition pharmaceutique. Le composé selon l'invention a une fonction de molécule double, peut servir d'inhibiteurs multi-cibles de nouvelle tyrosine kinase/histone désacétylase, peut simultanément obtenir l'effet de deux inhibiteurs, a une excellente activité biologique et des propriétés pharmacocinétiques, et présente un potentiel d'application en particulier dans le domaine du traitement de tumeurs.
(ZH)
提供了一种如通式(I)或(II)所示的含喹啉基的化合物或其药学上可接受的盐、溶剂化物、活性代谢物、多晶型物、同位素标记物或异构体,还提供了包含其的药物组合物以及所述化合物、药物组合物的用途。提供的化合物具有双重分子功能,可作为一类酪氨酸激酶/组蛋白去乙酰化酶的多靶点抑制剂,能够同时起到两类抑制剂的效果,具有优异的生物活性及药代动力学性能,尤其在肿瘤的治疗领域非常具有应用潜力。
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