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1. WO2020198728 - COMPOSITIONS, METHODS AND SYSTEMS FOR GAS VESICLE BASED CAVITATION

Publication Number WO/2020/198728
Publication Date 01.10.2020
International Application No. PCT/US2020/025608
International Filing Date 29.03.2020
IPC
A61K 49/22 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
49Preparations for testing in vivo
22Echographic preparations; Ultrasound imaging preparations
A61K 49/18 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
49Preparations for testing in vivo
06Nuclear magnetic resonance (NMR) contrast preparations; Magnetic resonance imaging (MRI) contrast preparations
18characterised by a special physical form, e.g. emulsions, microcapsules, liposomes
CPC
A61N 2007/0004
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
NELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
7Ultrasound therapy
0004Applications of ultrasound therapy
A61N 2007/0039
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
NELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
7Ultrasound therapy
0039using microbubbles
A61N 2007/0052
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
NELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
7Ultrasound therapy
0052using the same transducer for therapy and imaging
A61N 2007/0082
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
NELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
7Ultrasound therapy
0082Scanning transducers
A61N 7/00
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
NELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
7Ultrasound therapy
Applicants
  • CALIFORNIA INSTITUTE OF TECHNOLOGY [US]/[US]
Inventors
  • BAR-ZION, Avinoam D.
  • NOURMAHNAD, Atousa
  • MARESCA, David
  • SHAPIRO, Mikhail
Agents
  • CASH, Brian J.
  • STEINFL, Alessandro
  • BRUNO, Enrica
  • PEREZ, Ronald E.
  • DONG, Lun-Cong
  • XU, Jiancong
Priority Data
62/825,61228.03.2019US
62/895,55304.09.2019US
Publication Language English (EN)
Filing Language English (EN)
Designated States
Title
(EN) COMPOSITIONS, METHODS AND SYSTEMS FOR GAS VESICLE BASED CAVITATION
(FR) COMPOSITIONS, PROCÉDÉS ET SYSTÈMES POUR CAVITATION BASÉE SUR DES VÉSICULES GAZEUSES
Abstract
(EN)
The system and process of therapeutic and effective cavitation by using ultrasound to collapse gas vesicles as well as cavitate the bubbles produced from the collapsed gas vesicles. Therapeutic effect includes, but is not limited to lysing cells by cavitation. The cells expressing the gas vesicles can optionally be used as delivery cells to preform tasks such as transporting the gas vesicles into deep tissue areas, releasing compounds at the cavitation site, and more. The gas vesicles can optionally be modified to facilitate getting the bubbles near the cavitation targets by functionalizing the gas vesicles.
(FR)
La présente invention concerne un système et un procédé de cavitation thérapeutique et efficace par l'utilisation d'ultrasons pour comprimer des vésicules gazeuses ainsi que la cavitation des bulles produites par les vésicules gazeuses comprimées. L'effet thérapeutique comprend, entre autres, la lyse des cellules par cavitation. Les cellules exprimant les vésicules gazeuses peuvent éventuellement être utilisées comme cellules de distribution pour effectuer des tâches telles que le transport des vésicules gazeuses dans des zones de tissu profond, la libération de composés au niveau du site de cavitation, etc. Les vésicules gazeuses peuvent éventuellement être modifiées pour faciliter l'obtention des bulles à proximité des cibles de cavitation par fonctionnalisation des vésicules gazeuses.
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