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1. WO2020198711 - ANDROGEN RECEPTOR MODULATORS AND METHODS FOR USE AS PROTEOLYSIS TARGETING CHIMERA LIGANDS

Publication Number WO/2020/198711
Publication Date 01.10.2020
International Application No. PCT/US2020/025542
International Filing Date 27.03.2020
IPC
A61K 31/09 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
075Ethers or acetals
085having an ether linkage to aromatic ring nuclear carbon
09having two or more such linkages
A61K 31/10 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
095Sulfur, selenium or tellurium compounds, e.g. thiols
10Sulfides; Sulfoxides; Sulfones
A61K 31/255 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
21Esters, e.g. nitroglycerine, selenocyanates
255of sulfoxy acids or sulfur analogues thereof
A61K 51/04 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
51Preparations containing radioactive substances for use in therapy or testing in vivo
02characterised by the carrier
04Organic compounds
Applicants
  • ESSA PHARMA, INC. [CA]/[CA]
  • THE UNIVERSITY OF BRITISH COLUMBIA [CA]/[CA]
Inventors
  • ANDERSEN, Raymond John
  • ZHOU, Han-Jie
Agents
  • KEITH, Andrew S.
  • KUBOTA, Asako
  • VEITENHEIMER, Erich
  • TUSCAN, Michael S.
Priority Data
62/825,38728.03.2019US
Publication Language English (EN)
Filing Language English (EN)
Designated States
Title
(EN) ANDROGEN RECEPTOR MODULATORS AND METHODS FOR USE AS PROTEOLYSIS TARGETING CHIMERA LIGANDS
(FR) MODULATEURS DU RÉCEPTEUR DES ANDROGÈNES ET MÉTHODES ASSOCIÉES À UTILISER EN TANT QUE LIGANDS CHIMÈRES CIBLANT LA PROTÉOLYSE
Abstract
(EN)
The present invention relates to bifunctional Proteolysis Targeting Chimeric ligands (Protac compounds) comprising a ligase modulator/binder and a molecule that binds to a protein target of interest, and methods of treating various diseases and conditions with the Protac compounds, including diseases associated with androgen receptors.
(FR)
La présente invention concerne des ligands chimères bifonctionnels ciblant la protéolyse (composés Protac) comprenant un modulateur/liant de ligase et une molécule qui se lie à une protéine cible d'intérêt, et des méthodes de traitement de diverses maladies et états avec les composés Protac, notamment des maladies associées à des récepteurs des androgènes.
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