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1. WO2020198670 - INHIBITORS OF ATYPICAL PROTEIN KINASE C AND THEIR USE IN TREATING HEDGEHOG PATHWAY-DEPENDENT CANCERS

Publication Number WO/2020/198670
Publication Date 01.10.2020
International Application No. PCT/US2020/025437
International Filing Date 27.03.2020
IPC
C07D 471/04 2006.01
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
471Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/-C07D463/251
02in which the condensed system contains two hetero rings
04Ortho-condensed systems
C07D 493/08 2006.01
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
493Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
02in which the condensed system contains two hetero rings
08Bridged systems
C07D 498/04 2006.01
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
498Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
02in which the condensed system contains two hetero rings
04Ortho-condensed systems
Applicants
  • CANCER RESEARCH TECHNOLOGY LTD [GB]/[GB]
  • ORO, Anthony E. [US]/[US]
Inventors
  • ORO, Anthony E.
Agents
  • BUCHBINDER, Jenny L.
Priority Data
62/825,33428.03.2019US
Publication Language English (EN)
Filing Language English (EN)
Designated States
Title
(EN) INHIBITORS OF ATYPICAL PROTEIN KINASE C AND THEIR USE IN TREATING HEDGEHOG PATHWAY-DEPENDENT CANCERS
(FR) INHIBITEURS DE LA PROTÉINE KINASE C ATYPIQUE ET LEUR UTILISATION DANS LE TRAITEMENT DE CANCERS DÉPENDANT DE LA VOIE HEDGEHOG
Abstract
(EN)
Methods for treating hedgehog pathway-dependent cancers are provided. Aspects of the methods include the inhibition of hedgehog pathway-dependent cancer growth, proliferation, or metastasis that is promoted by hedgehog pathway signaling. In particular, methods of treating hedgehog pathway-dependent cancers with inhibitors of atypical protein kinase C iota are disclosed.
(FR)
La présente invention concerne des méthodes de traitement de cancers dépendant de la voie hedgehog. Selon des aspects, les méthodes comprennent l'inhibition de la croissance, de la prolifération ou de la métastase du cancer dépendant de la voie hedgehog qui est favorisée par la signalisation de la voie hedgehog. En particulier, l'invention concerne des procédés de traitement de cancers dépendants de la voie hedgehog à l'aide d'inhibiteurs de la protéine kinase C atypique.
Latest bibliographic data on file with the International Bureau