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1. WO2020198661 - CHIMERIC PROTEINS AND CHIMERIC PROTEIN COMPLEXES DIRECTED TO FMS-LIKE TYROSINE KINASE 3 (FLT3)

Publication Number WO/2020/198661
Publication Date 01.10.2020
International Application No. PCT/US2020/025421
International Filing Date 27.03.2020
IPC
A61K 38/00 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
38Medicinal preparations containing peptides
A61K 38/17 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
38Medicinal preparations containing peptides
16Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
17from animals; from humans
A61K 39/00 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
39Medicinal preparations containing antigens or antibodies
A61P 37/04 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
37Drugs for immunological or allergic disorders
02Immunomodulators
04Immunostimulants
C07K 14/47 2006.01
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
14Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
435from animals; from humans
46from vertebrates
47from mammals
C07K 14/475 2006.01
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
14Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
435from animals; from humans
475Growth factors; Growth regulators
Applicants
  • ORIONIS BIOSCIENCES, INC. [US]/[US]
  • ORIONIS BIOSCIENCES BV [BE]/[BE]
Inventors
  • KLEY, Nikolai
  • DEPLA, Erik
  • ZABEAU, Lennart
  • TAVERNIER, Jan
Agents
  • ALTIERI, Stephen, L.
  • CURRIE, Matthew, T.
  • HAYMAN, Mark, L.
  • FRANK, Steven, J.
  • LIN, Yi-chia
Priority Data
62/825,58028.03.2019US
Publication Language English (EN)
Filing Language English (EN)
Designated States
Title
(EN) CHIMERIC PROTEINS AND CHIMERIC PROTEIN COMPLEXES DIRECTED TO FMS-LIKE TYROSINE KINASE 3 (FLT3)
(FR) PROTÉINES CHIMÉRIQUES ET COMPLEXES PROTÉIQUES CHIMÉRIQUES DIRIGÉS CONTRE LA TYROSINE KINASE 3 DE TYPE FMS (FLT3)
Abstract
(EN)
Chimeric proteins or chimeric protein complexes, such as an Fc-based chimeric protein complexes directed to FMS-like tyrosine kinase 3 (FLT3), optionally composed of a FMS-like tyrosine kinase 3L (FLT3L) domain and human cytokines, which find use in, e.g., cancer treatments, are described.
(FR)
La présente invention porte sur des protéines chimériques ou des complexes protéiques chimériques, tel qu'un complexe de protéines chimériques à base de Fc, dirigés contre la tyrosine kinase 3 de type FMS (FLT3), facultativement composé d'un domaine de tyrosine kinase 3L de type FMS (FLT3L) et de cytokines humaines, qui trouvent une utilisation dans, par exemple, des traitements anticancéreux.
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