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1. WO2020198659 - FMS-LIKE TYROSINE KINASE 3 LIGAND (FLT3L)-BASED CHIMERIC PROTEINS

Publication Number WO/2020/198659
Publication Date 01.10.2020
International Application No. PCT/US2020/025419
International Filing Date 27.03.2020
IPC
A61K 38/00 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
38Medicinal preparations containing peptides
C07K 19/00 2006.01
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
19Hybrid peptides
C12N 15/12 2006.01
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
15Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
09Recombinant DNA-technology
11DNA or RNA fragments; Modified forms thereof
12Genes encoding animal proteins
C12N 15/62 2006.01
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
15Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
09Recombinant DNA-technology
11DNA or RNA fragments; Modified forms thereof
62DNA sequences coding for fusion proteins
Applicants
  • ORIONIS BIOSCIENCES, INC. [US]/[US]
  • VIB VZW [BE]/[BE]
  • UNIVERSITEIT GENT [BE]/[BE]
Inventors
  • KLEY, Nikolai
  • TAVERNIER, Jan
  • VAN PARYS, Alexander
Agents
  • ALTIERI, Stephen, L.
  • LIN, Yi-chia
  • CURRIE, Matthew, T.
  • HAYMAN, Mark, L.
  • FRANK, Steven, J.
Priority Data
62/825,57928.03.2019US
Publication Language English (EN)
Filing Language English (EN)
Designated States
Title
(EN) FMS-LIKE TYROSINE KINASE 3 LIGAND (FLT3L)-BASED CHIMERIC PROTEINS
(FR) PROTÉINES CHIMÉRIQUES BASÉES SUR LE LIGAND DE LA TYROSINE KINASE-3 DE TYPE FMS (FLT3L)
Abstract
(EN)
FMS-like tyrosine kinase 3L (FLT3L) fused to human cytokines, which find use in, e.g., cancer treatments, is described. Accordingly, in some aspects, the present invention relates to a chimeric protein comprising a targeting moiety which comprises a single copy of FMS-like tyrosine kinase 3 ligand (FLT3L), or a portion thereof. In various embodiments, the targeting moiety functionally modulates the antigen or receptor of interest. In some embodiments, the targeting moiety binds but does not functionally modulate the antigen or receptor of interest.
(FR)
L'invention concerne le ligand de la tyrosine kinase-3 de type FMS (FLT3L) fusionné à des cytokines humaines, qui s'utilise, par exemple, dans des traitements anticancéreux. Par conséquent, selon certains aspects, la présente invention concerne une protéine chimérique comprenant une fraction à rôle de ciblage qui comprend une copie unique du ligand de la tyrosine kinase-3 de type FMS (FLT3L), ou une partie de celle-ci. Dans divers modes de réalisation, la fraction à rôle de ciblage module fonctionnellement l'antigène ou le récepteur d'intérêt. Dans certains modes de réalisation, la fraction à rôle de ciblage se lie à l'antigène ou au récepteur d'intérêt mais ne permet pas de le moduler fonctionnellement.
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