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1. WO2020198646 - INTRACELLULAR DELIVERY AND MITOCHONDRIAL TARGETING BY FLUORINATION

Publication Number WO/2020/198646
Publication Date 01.10.2020
International Application No. PCT/US2020/025382
International Filing Date 27.03.2020
IPC
C09D 133/08 2006.01
CCHEMISTRY; METALLURGY
09DYES; PAINTS; POLISHES; NATURAL RESINS; ADHESIVES; COMPOSITIONS NOT OTHERWISE PROVIDED FOR; APPLICATIONS OF MATERIALS NOT OTHERWISE PROVIDED FOR
DCOATING COMPOSITIONS, e.g. PAINTS, VARNISHES OR LACQUERS; FILLING PASTES; CHEMICAL PAINT OR INK REMOVERS; INKS; CORRECTING FLUIDS; WOODSTAINS; PASTES OR SOLIDS FOR COLOURING OR PRINTING; USE OF MATERIALS THEREFOR
133Coating compositions based on homopolymers or copolymers of compounds having one or more unsaturated aliphatic radicals, each having only one carbon-to-carbon double bond, and at least one being terminated by only one carboxyl radical, or of salts, anhydrides, esters, amides, imides, or nitriles thereof; Coating compositions based on derivatives of such polymers
04Homopolymers or copolymers of esters
06of esters containing only carbon, hydrogen and oxygen, the oxygen atom being present only as part of the carboxyl radical
08Homopolymers or copolymers of acrylic acid esters
C09D 133/14 2006.01
CCHEMISTRY; METALLURGY
09DYES; PAINTS; POLISHES; NATURAL RESINS; ADHESIVES; COMPOSITIONS NOT OTHERWISE PROVIDED FOR; APPLICATIONS OF MATERIALS NOT OTHERWISE PROVIDED FOR
DCOATING COMPOSITIONS, e.g. PAINTS, VARNISHES OR LACQUERS; FILLING PASTES; CHEMICAL PAINT OR INK REMOVERS; INKS; CORRECTING FLUIDS; WOODSTAINS; PASTES OR SOLIDS FOR COLOURING OR PRINTING; USE OF MATERIALS THEREFOR
133Coating compositions based on homopolymers or copolymers of compounds having one or more unsaturated aliphatic radicals, each having only one carbon-to-carbon double bond, and at least one being terminated by only one carboxyl radical, or of salts, anhydrides, esters, amides, imides, or nitriles thereof; Coating compositions based on derivatives of such polymers
04Homopolymers or copolymers of esters
14of esters containing halogen, nitrogen, sulfur or oxygen atoms in addition to the carboxy oxygen
C09D 133/16 2006.01
CCHEMISTRY; METALLURGY
09DYES; PAINTS; POLISHES; NATURAL RESINS; ADHESIVES; COMPOSITIONS NOT OTHERWISE PROVIDED FOR; APPLICATIONS OF MATERIALS NOT OTHERWISE PROVIDED FOR
DCOATING COMPOSITIONS, e.g. PAINTS, VARNISHES OR LACQUERS; FILLING PASTES; CHEMICAL PAINT OR INK REMOVERS; INKS; CORRECTING FLUIDS; WOODSTAINS; PASTES OR SOLIDS FOR COLOURING OR PRINTING; USE OF MATERIALS THEREFOR
133Coating compositions based on homopolymers or copolymers of compounds having one or more unsaturated aliphatic radicals, each having only one carbon-to-carbon double bond, and at least one being terminated by only one carboxyl radical, or of salts, anhydrides, esters, amides, imides, or nitriles thereof; Coating compositions based on derivatives of such polymers
04Homopolymers or copolymers of esters
14of esters containing halogen, nitrogen, sulfur or oxygen atoms in addition to the carboxy oxygen
16Homopolymers or copolymers of esters containing halogen atoms
Applicants
  • THE TEXAS A&M UNIVERSITY SYSTEM [US]/[US]
Inventors
  • ZHU, Lin
  • LIU, Yin
  • TU, Ying
Agents
  • GOPALAKRISHNAN, Lekha
  • MOON, William, Allen
  • THOMAS, Daniel, A.
  • UDOVICH, Samuel, A.
  • LOVELL, David, A.
  • MOORE, Stanley, R.
Priority Data
62/824,79127.03.2019US
Publication Language English (EN)
Filing Language English (EN)
Designated States
Title
(EN) INTRACELLULAR DELIVERY AND MITOCHONDRIAL TARGETING BY FLUORINATION
(FR) ADMINISTRATION INTRACELLULAIRE ET CIBLAGE MITOCHONDRIAL PAR FLUORATION
Abstract
(EN)
In an embodiment, the present disclosure relates to a targeting platform that includes a targeted delivery system including an agent. In some embodiments, the targeted delivery system is modified by fluorination. In some embodiments, the targeted delivery system is electrically charge neutral. In a further embodiment, the present disclosure relates to a method that includes fluorinating a targeting compound with a fluorinating reagent and loading an agent with the fluorinated targeting compound to thereby form a micelle. In an additional embodiment, the present disclosure relates to a targeting platform that includes a fluorinated polymeric system including an agent. In another embodiment, the present disclosure relates to a method that includes fluorinating a targeting compound with a fluorinating reagent and loading an agent with the fluorinated targeting compound to thereby form a micelle. Additionally, the method can include administering the fluorinated targeting compound to a subject.
(FR)
Dans un mode de réalisation, la présente invention concerne une plateforme de ciblage qui comprend un système d'administration ciblée comprenant un agent. Dans certains modes de réalisation, le système d'administration ciblée est modifié par fluoration. Dans certains modes de réalisation, le système d'administration ciblée est électriquement neutre. Dans un autre mode de réalisation, la présente invention concerne un procédé qui comprend la fluoration d'un composé de ciblage avec un réactif de fluoration et la charge d'un agent avec le composé de ciblage fluoré pour former ainsi une micelle. Dans un autre mode de réalisation, la présente invention concerne une plateforme de ciblage qui comprend un système polymère fluoré comprenant un agent. Dans un autre mode de réalisation, la présente invention concerne un procédé qui comprend la fluoration d'un composé de ciblage avec un réactif de fluoration et la charge d'un agent avec le composé de ciblage fluoré pour former ainsi une micelle. De plus, le procédé peut comprendre l'administration du composé de ciblage fluoré à un sujet.
Latest bibliographic data on file with the International Bureau