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1. WO2020198529 - SUBSTITUTED AMINO-THIOL AND AMINO-DISULFIDE COMPOUNDS, AND USES THEREOF

Publication Number WO/2020/198529
Publication Date 01.10.2020
International Application No. PCT/US2020/025067
International Filing Date 26.03.2020
IPC
A61K 31/145 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
13Amines, e.g. amantadine
145having sulfur atoms, e.g. thiurams ; Sulfinylamines (-N=SO); Sulfonylamines
A61P 1/16 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
1Drugs for disorders of the alimentary tract or the digestive system
16for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
A61P 25/28 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
25Drugs for disorders of the nervous system
28for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
Applicants
  • THE REGENTS OF THE UNIVERSITY OFCALIFORNIA [US]/[US]
Inventors
  • DOHIL, Ranjan
  • BALLATORE, Carlo
Agents
  • BAKER JR., Joseph, R.
Priority Data
62/823,89226.03.2019US
Publication Language English (EN)
Filing Language English (EN)
Designated States
Title
(EN) SUBSTITUTED AMINO-THIOL AND AMINO-DISULFIDE COMPOUNDS, AND USES THEREOF
(FR) COMPOSÉS DE TYPE AMINO-THYOL ET AMINO-DISULFIDE SUBSTITUÉS ET LEURS UTILISATIONS
Abstract
(EN)
The disclosure provides for new substituted cysteamine and cystamine compounds, pharmaceutical compositions made thereof, and methods thereof including the treatment of any disease or disorder in a subject that can benefit from one or more of the bioprotective effects of the compounds, including but not limited to, binding of cystine, reducing oxidative stress, increasing adiponectin levels and/or increasing brain-derived neurotrophic factors. Examples of such disease and disorders, include but are not limited to, cystinosis, and fatty liver diseases.
(FR)
L'invention concerne de nouveaux composés de type cystéamine et de cystamine substituées, des compositions pharmaceutiques les comportant, ainsi que des méthodes utilisant celles-ci comprenant le traitement de toute maladie ou pathologie chez le patient pouvant bénéficier d'un ou de plusieurs des effets bio-protecteurs des composés, lesquels comprennent, mais sans y être limités, le fait de se lier à la cystine, de diminuer le stress oxydant d'augmenter le niveau de l'adiponectine et/ou d'augmenter des facteurs neurotrophiques dérivés du cerveau. Des exemples d'une telle maladie et de telles pathologies comprennent, sans y être limités, la cystinose et les stéatoses hépatiques.
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