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1. WO2020198370 - THERAPEUTIC CD47 ANTIBODIES

Publication Number WO/2020/198370
Publication Date 01.10.2020
International Application No. PCT/US2020/024730
International Filing Date 25.03.2020
IPC
C07K 16/24 2006.01
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
16Immunoglobulins, e.g. monoclonal or polyclonal antibodies
18against material from animals or humans
24against cytokines, lymphokines or interferons
A61K 35/15 2015.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
35Medicinal preparations containing materials or reaction products thereof with undetermined constitution
12Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
14Blood; Artificial blood
15Cells of the myeloid line, e.g. granulocytes, basophils, eosinophils, neutrophils, leucocytes, monocytes, macrophages or mast cells; Myeloid precursor cells; Antigen-presenting cells, e.g. dendritic cells
A61K 35/28 2015.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
35Medicinal preparations containing materials or reaction products thereof with undetermined constitution
12Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
28Bone marrow; Haematopoietic stem cells; Mesenchymal stem cells of any origin, e.g. adipose-derived stem cells
A61K 38/17 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
38Medicinal preparations containing peptides
16Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
17from animals; from humans
A61K 39/395 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
39Medicinal preparations containing antigens or antibodies
395Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
C07K 16/28 2006.01
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
16Immunoglobulins, e.g. monoclonal or polyclonal antibodies
18against material from animals or humans
28against receptors, cell surface antigens or cell surface determinants
Applicants
  • ARCH ONCOLOGY, INC. [US]/[US]
Inventors
  • MANNING, Pamela
  • PURO, Robyn
  • ALMAGRO, Juan
  • KARR, Robert
  • CHAKRABORTY, Prabir
  • PEREIRA, Daniel
  • WILSON, W. Casey
Agents
  • REXER, Charles
Priority Data
62/823,30325.03.2019US
62/877,06922.07.2019US
62/909,60302.10.2019US
Publication Language English (EN)
Filing Language English (EN)
Designated States
Title
(EN) THERAPEUTIC CD47 ANTIBODIES
(FR) ANTICORPS CD47 THÉRAPEUTIQUES
Abstract
(EN)
Provided are anti-CD47 monoclonal antibodies (anti-CD47 mAbs) with distinct functional profiles as described herein, methods to generate anti-CD47 mAbs, and to methods of using these anti-CD47 mAbs as therapeutics for the prevention and treatment of solid and hematological cancers, ischemia-reperfusion injury, cardiovascular diseases, autoimmune diseases, inflammatory diseases or as diagnostics for determining the level of CD47 in tissue samples.
(FR)
L'invention concerne des anticorps monoclonaux anti-CD47 (mAb anti-CD47) ayant des profils fonctionnels distincts tels que décrits dans la description, des procédés pour générer des anticorps anti-CD47, et des procédés d'utilisation de ces anticorps anti-CD47 en tant qu'agents thérapeutiques pour la prévention et le traitement de cancers solides et hématologiques, d'une lésion d'ischémie-reperfusion, de maladies cardiovasculaires, de maladies auto-immunes, de maladies inflammatoires ou en tant que diagnostic pour déterminer le niveau de CD47 dans des échantillons de tissu.
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