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1. WO2020198320 - METHODS AND COMPOSITIONS RELATED TO ENHANCING RETROVIRAL VECTOR ENTRY AND INTEGRATION IN HOST CELLS

Publication Number WO/2020/198320
Publication Date 01.10.2020
International Application No. PCT/US2020/024651
International Filing Date 25.03.2020
IPC
C12N 15/86 2006.01
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
15Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
09Recombinant DNA-technology
63Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
79Vectors or expression systems specially adapted for eukaryotic hosts
85for animal cells
86Viral vectors
C07C 15/52 2006.01
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
CACYCLIC OR CARBOCYCLIC COMPOUNDS
15Cyclic hydrocarbons containing only six-membered aromatic rings as cyclic part
40substituted by unsaturated hydrocarbon radicals
50polycyclic non-condensed
52containing a group with formula
Applicants
  • THE SCRIPPS RESEARCH INSTITUTE [US]/[US]
Inventors
  • TORBETT, Bruce, E.
  • SNYDER, Scott, A.
  • TIMBERLAKE, Nina
Agents
  • FITTING, Thomas
  • WANG, Hugh
Priority Data
62/824,60527.03.2019US
Publication Language English (EN)
Filing Language English (EN)
Designated States
Title
(EN) METHODS AND COMPOSITIONS RELATED TO ENHANCING RETROVIRAL VECTOR ENTRY AND INTEGRATION IN HOST CELLS
(FR) PROCÉDÉS ET COMPOSITIONS LIÉS À L'AMÉLIORATION DE L'ENTRÉE ET DE L'INTÉGRATION DE VECTEURS RÉTROVIRAUX DANS DES CELLULES HÔTES
Abstract
(EN)
The present invention provides methods for enhancing transduction efficiency of a viral vector into a host cell such as a stem cell. The methods involve transducing the host cell with the vector in the presence of a resveratrol oligomer compound (e.g., α-viniferin or caraphenol A or analog compound thereof). Also provided in the invention are kits or pharmaceutical combinations for delivering a therapeutic agent into a target cell with enhanced targeting frequency and payload delivery. The kits or pharmaceutical combinations typically contain a viral vector encoding the therapeutic agent, and a resveratrol oligomer compound.
(FR)
La présente invention concerne des procédés pour améliorer l'efficacité de transduction d'un vecteur viral dans une cellule hôte telle qu'une cellule souche. Les procédés mettent en œuvre la transduction de la cellule hôte avec le vecteur en présence d'un composé oligomère de resvératrol (par exemple, une α-viniférine, un caraphénol A ou un composé analogue de ceux-ci). La présente invention concerne en outre des trousses ou des combinaisons pharmaceutiques pour transporter un agent thérapeutique dans une cellule cible avec une fréquence de ciblage et un transfert de charge active améliorés. Les trousses ou combinaisons pharmaceutiques contiennent typiquement un vecteur viral codant pour l'agent thérapeutique et un composé d'oligomère de resvératrol.
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