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1. WO2020198305 - HONEYCOMB-SHAPED ELECTRO-NEURAL INTERFACE FOR RETINAL PROSTHESIS

Publication Number WO/2020/198305
Publication Date 01.10.2020
International Application No. PCT/US2020/024619
International Filing Date 25.03.2020
IPC
A61N 1/05 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
NELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
1Electrotherapy; Circuits therefor
02Details
04Electrodes
05for implantation or insertion into the body, e.g. heart electrode
A61N 1/36 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
NELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
1Electrotherapy; Circuits therefor
18Applying electric currents by contact electrodes
32alternating or intermittent currents
36for stimulation, e.g. heart pace-makers
A61F 9/007 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
FFILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
9Methods or devices for treatment of the eyes; Devices for putting in contact-lenses; Devices to correct squinting; Apparatus to guide the blind; Protective devices for the eyes, carried on the body or in the hand
007Methods or devices for eye surgery
Applicants
  • THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIVERSITY [US]/[US]
Inventors
  • PALANKER, Daniel, V.
  • FLORES, Thomas
Agents
  • MCFARLANE, Thomas, J.
  • JACOBS, Ron
  • LODENKAMPER, Robert
Priority Data
62/823,39525.03.2019US
Publication Language English (EN)
Filing Language English (EN)
Designated States
Title
(EN) HONEYCOMB-SHAPED ELECTRO-NEURAL INTERFACE FOR RETINAL PROSTHESIS
(FR) INTERFACE ÉLECTRO-NEURONALE SOUS FORME DE NID D'ABEILLES POUR PROTHÈSE RÉTINIENNE
Abstract
(EN)
We provide a 3-dimensional configuration of an electrode array for neural cell stimulation designed to leverage migration of retinal cells into voids in the subretinal space. Walls surrounding each pixel align the electric field vertically, matching the orientation of bipolar cells in the retina, and thereby reduce the stimulation threshold. These walls also decouple the field penetration depth from the pixel width, enabling a decrease of the pixel size down to cellular dimensions. Inner retinal cells migrate into the electrode cavities, which enables very efficient stimulation. Due to 1-dimensional alignment of electric field along the cavities, stimulation threshold current density does not increase significantly with the reduced pixel size, unlike the quadratic increase seen with planar arrays.
(FR)
L'invention concerne une configuration tridimensionnelle d'un réseau d'électrodes permettant une stimulation de cellules neuronales conçue pour tirer partie de la migration de cellules rétiniennes dans des vides de l'espace sous-rétinien. Des parois entourant chaque pixel alignent verticalement le champ électrique, adaptant l'orientation des cellules bipolaires dans la rétine, et réduisant ainsi le seuil de stimulation. Ces parois séparent également la profondeur de pénétration de champ de la largeur de pixel, ce qui permet une diminution de la taille de pixels jusqu'à des dimensions cellulaires. Les cellules rétiniennes internes migrent dans les cavités d'électrode, ce qui permet une stimulation très efficace. En raison de l'alignement unidimensionnel du champ électrique le long des cavités, la densité de courant de seuil de stimulation n'augmente pas de manière significative avec la taille de pixel réduite, contrairement à l'augmentation quadratique observée avec des réseaux plans.
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