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1. WO2020198301 - INHIBITOR OF MIGRATION OF CANCER CELLS AND METHODS OF TREATING CANCER CELLS METASTASIS

Note: Text based on automatic Optical Character Recognition processes. Please use the PDF version for legal matters

[ EN ]

In the claims:

1. A method for treating against a cancer comprising administering a compound, a tautomer, or a pharmaceutically acceptable salt thereof, in an amount effective for inhibiting metastasis of the cancer, wherein the compound is represented by the formula:


wherein each Ri is independent of the other and represents a halogen atom selected from the group consisting ofbromo, chloro, fluoro and iodo.

2. The method according to claim 1, wherein each Ri is the same.

3. The method according to claim 2, wherein at least one Ri represents chloro.

4. The method according to claim 2, wherein each Ri represents chloro.

5. The method according to any one of claims 1 through 4, wherein the cancer is one in which

RACK1 functions as a positive regulator for cancer cell migration and metastasis.

6. The method according to any of claims 1, 2, 3, 4, or 5, wherein the cancer is breast cancer.

7. The method according to any of claims 1, 2, 3, 4, or 5, wherein the cancer is gliobastoma.

8. A cancer inhibitor composition for inhibiting cancer cells from cell migration and metastasis in which RACK1 functions as a positive regulator for cancer cell migration and metastasis, said cancer inhibitor composition comprising, as an inhibitor, a compound, a tautomer, or a pharmaceutically acceptable salt thereof, wherein the compound is represented by the formula:

wherein each Ri is independent of the other and represents a halogen atom selected from the group consisting ofbromo, chloro, fluoro and iodo.

9. The cancer inhibitor composition according to claim 8, wherein the RACK1 inhibitor further comprises a carrier.

10. The cancer inhibitor composition according to claim 8 or 9, wherein each Ri is the same.

11. The cancer inhibitor composition according to claim 8 or 9, wherein at least one Ri represents chloro.

12. The cancer inhibitor composition according to claim 8 or 9, wherein each Ri represents chloro.

13. Use of a therapeutically effective amount of a cancer inhibitor according to claim 8 for treating against cancer metastasis.