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1. WO2020198301 - INHIBITOR OF MIGRATION OF CANCER CELLS AND METHODS OF TREATING CANCER CELLS METASTASIS

Publication Number WO/2020/198301
Publication Date 01.10.2020
International Application No. PCT/US2020/024610
International Filing Date 25.03.2020
IPC
A13 41/
A61K 31/4196 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
33Heterocyclic compounds
395having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
41having five-membered rings with two or more ring hetero atoms, at least one of which is nitrogen, e.g. tetrazole
41961,2,4-Triazoles
A61P 35/04 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
35Antineoplastic agents
04specific for metastasis
CPC
A61K 31/4196
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
33Heterocyclic compounds
395having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
41having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
41961,2,4-Triazoles
A61P 35/04
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
35Antineoplastic agents
04specific for metastasis
Applicants
  • HOWARD UNIVERSITY [US]/[US]
  • GEORGETOWN UNIVERSITY [US]/[US]
  • ULLAH, Heyamet [US]/[US]
  • DAKSHANAMURTHY, Sivanesan [US]/[US]
Inventors
  • ULLAH, Heyamet
  • DAKSHANAMURTHY, Sivanesan
Agents
  • TOWNSLEY, Alan C.
  • BIRD, John M.
  • EMERY, David P.
Priority Data
62/823,27825.03.2019US
Publication Language English (EN)
Filing Language English (EN)
Designated States
Title
(EN) INHIBITOR OF MIGRATION OF CANCER CELLS AND METHODS OF TREATING CANCER CELLS METASTASIS
(FR) INHIBITEUR DE MIGRATION DE CELLULES CANCÉREUSES ET MÉTHODES DE TRAITEMENT DE MÉTASTASES DE CELLULES CANCÉREUSES
Abstract
(EN)
A method for treating against, or at least inhibiting or suppressing, the proliferation of a cancer involves administering a compound, a tautomer, or a pharmaceutically acceptable salt thereof, in an amount effective for inhibiting metastasis of cancer cells, wherein the compound is represented by the formula (1): wherein each R1 is independent of the other and represents a halogen atom selected from the group consisting of bromo, chloro, fluoro and iodo.
(FR)
La présente invention concerne une méthode de traitement, ou du moins d'inhibition ou de suppression, de la prolifération d'un cancer consistant à administrer un composé, un tautomère, ou un sel pharmaceutiquement acceptable de ce premier, en une quantité efficace pour inhiber des métastases de cellules cancéreuses, le composé étant représenté par la formule (I) : dans laquelle chaque R1 est indépendant de l'autre et représente un atome d'halogène choisi dans le groupe constitué par le brome, le chlore, le fluor et l'iode.
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