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1. WO2020198275 - COMPOSITIONS AND METHODS FOR REDUCING TACTILE DYSFUNCTION, ANXIETY, AND SOCIAL IMPAIRMENT

Publication Number WO/2020/198275
Publication Date 01.10.2020
International Application No. PCT/US2020/024564
International Filing Date 25.03.2020
IPC
A61K 35/74 2015.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
35Medicinal preparations containing materials or reaction products thereof with undetermined constitution
66Microorganisms or materials therefrom
74Bacteria
A61K 38/08 2019.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
38Medicinal preparations containing peptides
04Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
08Peptides having 5 to 11 amino acids
A61K 38/14 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
38Medicinal preparations containing peptides
04Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
14Peptides containing saccharide radicals; Derivatives thereof
Applicants
  • PRESIDENT AND FELLOWS OF HARVARD COLLEGE [US]/[US]
Inventors
  • GINTY, David, D,
  • OREFICE, Lauren, L.
  • LEE, Jinbo
Agents
  • CAUBLE, David, F
  • ALAM, Saad
  • AMUNDSEN, Eric, L
  • BAKER, Hunter
  • BALICH, Jason, W.
Priority Data
62/823,41925.03.2019US
Publication Language English (EN)
Filing Language English (EN)
Designated States
Title
(EN) COMPOSITIONS AND METHODS FOR REDUCING TACTILE DYSFUNCTION, ANXIETY, AND SOCIAL IMPAIRMENT
(FR) COMPOSITIONS ET MÉTHODES POUR RÉDUIRE UN DYSFONCTIONNEMENT TACTILE, L'ANXIÉTÉ ET UNE DÉFICIENCE SOCIALE
Abstract
(EN)
The present invention provides novel peripherally-restricted benzodiazepines with reduced blood brain barrier permeability and methods of use thereof for reducing tactile dysfunction, social impairment, and anxiety in a subject diagnosed with Autism Spectrum Disorder, Rett syndrome, Phelan McDermid syndrome, or Fragile X syndrome.
(FR)
La présente invention concerne de nouvelles benzodiazépines à restriction périphérique ayant une perméabilité réduite de la barrière hémato-encéphalique et des procédés d'utilisation de ceux-ci pour réduire un dysfonctionnement tactile, une déficience sociale et l'anxiété chez un sujet ayant été diagnostiqué avec un trouble du spectre autistique, un syndrome de Rett, un syndrome de Phelan McDermid, ou un syndrome du X fragile.
Latest bibliographic data on file with the International Bureau