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1. WO2020198266 - SMALL MOLECULE INHIBITORS OF GALECTIN-3

Publication Number WO/2020/198266
Publication Date 01.10.2020
International Application No. PCT/US2020/024548
International Filing Date 25.03.2020
IPC
C07H 19/056 2006.01
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
HSUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
19Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro derivatives thereof
02sharing nitrogen
04Heterocyclic radicals containing only nitrogen as ring hetero atom
056Triazole or tetrazole radicals
CPC
A61P 1/16
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
1Drugs for disorders of the alimentary tract or the digestive system
16for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
A61P 13/12
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
13Drugs for disorders of the urinary system
12of the kidneys
A61P 35/00
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
35Antineoplastic agents
A61P 9/10
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
9Drugs for disorders of the cardiovascular system
10for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
C07D 405/14
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
405Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
14containing three or more hetero rings
C07D 417/14
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
417Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
14containing three or more hetero rings
Applicants
  • BRISTOL-MYERS SQUIBB COMPANY [US]/[US]
Inventors
  • LIU, Chunjian
  • YOON, David S.
  • WANG, Wei
  • FENG, Jianxin
  • ELLSWORTH, Bruce A.
  • REGUEIRO-REN, Alicia
Agents
  • SUN, Jing G.
  • BARBIC, Andrej
  • BELLOMY, Gregory R.
  • CHAO, Yuan
  • CLAUSS, Isabelle M.
  • COULTER, Kathryn
  • DELAUNEY, Ashton J.
  • FARQUHARSON-TORRES, Serena
  • GOLIAN, Paul D.
  • GREENBLATT, Gary D.
  • GUO, Z. Angela
  • HADAD, Henry
  • HAI, Bing
  • HAN, Bo
  • JACOBSEN, Barry H.
  • KORSEN, Elliott
  • LAUB, Friedrich Bernhard
  • LIU, Hong
  • VANATTEN, Mary K.
  • VOM WEGE, Julia
  • WALSH, Brian J.
Priority Data
62/823,68426.03.2019US
Publication Language English (EN)
Filing Language English (EN)
Designated States
Title
(EN) SMALL MOLECULE INHIBITORS OF GALECTIN-3
(FR) INHIBITEURS À PETITES MOLÉCULES DE GALECTINE -3
Abstract
(EN)
The present disclosure relates to compounds of Formula (I), which inhibit Gal-3, and include pharmaceutically acceptable salts, compositions comprising such compounds, and methods using and making such compounds and compositions.
(FR)
La présente invention concerne des composés de formule (I), qui inhibent la Gal-3, et comprennent des sels pharmaceutiquement acceptables, des compositions comprenant de tels composés, et des procédés d'utilisation et de production de tels composés et compositions.
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