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1. WO2020198144 - CHMP2A AS A REGULATOR OF NATURAL KILLER CELL-MEDIATED ACTIVITY

Publication Number WO/2020/198144
Publication Date 01.10.2020
International Application No. PCT/US2020/024218
International Filing Date 23.03.2020
IPC
C40B 40/08 2006.01
CCHEMISTRY; METALLURGY
40COMBINATORIAL TECHNOLOGY
BCOMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES, IN SILICO LIBRARIES
40Libraries per se, e.g. arrays, mixtures
04Libraries containing only organic compounds
06Libraries containing nucleotides or polynucleotides, or derivatives thereof
08Libraries containing RNA or DNA which encodes proteins, e.g. gene libraries
C12N 15/11 2006.01
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
15Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
09Recombinant DNA-technology
11DNA or RNA fragments; Modified forms thereof
A61P 35/00 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
35Antineoplastic agents
Applicants
  • THE REGENTS OF THE UNIVERSITY OF CALIFORNIA [US]/[US]
Inventors
  • KAUFMAN, Dan S.
  • BERNAREGGI, Davide
  • RICH, Jeremy
  • XIE, Qi
Agents
  • WARREN, William L.
  • WIGLEY, David E.
  • PAPPAS, Peter G.
  • GRIFFIN, III, Malvern U.
  • KING, Kevin W.
  • CHAN, Christopher J.
  • HUROWITZ, Haley
Priority Data
62/822,25922.03.2019US
Publication Language English (EN)
Filing Language English (EN)
Designated States
Title
(EN) CHMP2A AS A REGULATOR OF NATURAL KILLER CELL-MEDIATED ACTIVITY
(FR) CHMP2A EN TANT QUE RÉGULATEUR DE L'ACTIVITÉ INDUITE PAR DES CELLULES TUEUSES NATURELLES
Abstract
(EN)
Methods and compositions for increasing tumor cell sensitivity to natural killer cell-mediated toxicity by inhibiting CHMP2A or other endosomal sorting complex required for transport in the tumor cell.
(FR)
L'invention concerne des procédés et des compositions pour augmenter la sensibilité de cellules tumorales à la toxicité induite par les cellules tueuses naturelles par inhibition de CHMP2A ou d'un autre complexe de tri endosomique requis pour le transport dans la cellule tumorale.
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