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1. WO2020198015 - TANNIC ACID/FE (III) NANOPARTICLES AND METHODS OF DRUG DELIVERY

Publication Number WO/2020/198015
Publication Date 01.10.2020
International Application No. PCT/US2020/023876
International Filing Date 20.03.2020
IPC
A61K 38/26 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
38Medicinal preparations containing peptides
16Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
17from animals; from humans
22Hormones
26Glucagons
A61K 47/34 2017.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
47Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
30Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
34Macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyesters, polyamino acids, polysiloxanes, polyphosphazines, copolymers of polyalkylene glycol or poloxamers
A61K 47/69 2017.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
47Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
50the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
69the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit
A61K 9/51 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
9Medicinal preparations characterised by special physical form
48Preparations in capsules, e.g. of gelatin, of chocolate
50Microcapsules
51Nanocapsules
B82Y 5/00 2011.01
BPERFORMING OPERATIONS; TRANSPORTING
82NANOTECHNOLOGY
YSPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES; MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES; MANUFACTURE  OR TREATMENT OF NANOSTRUCTURES
5Nanobiotechnology or nanomedicine, e.g. protein engineering or drug delivery
B82Y 40/00 2011.01
BPERFORMING OPERATIONS; TRANSPORTING
82NANOTECHNOLOGY
YSPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES; MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES; MANUFACTURE  OR TREATMENT OF NANOSTRUCTURES
40Manufacture or treatment of nanostructures
Applicants
  • THE JOHNS HOPKINS UNIVERSITY [US]/[US]
  • SUN YAT-SEN UNIVERSITY [CN]/[CN]
Inventors
  • MAO, Hai-Quan
  • HE, Zhiyu
  • HU, Yizong
  • CHEN, Yongming
  • LIU, Lixin
Agents
  • CONTRERA, Joseph
Priority Data
201910222916.422.03.2019CN
62/822,08522.03.2019US
Publication Language English (EN)
Filing Language English (EN)
Designated States
Title
(EN) TANNIC ACID/FE (III) NANOPARTICLES AND METHODS OF DRUG DELIVERY
(FR) NANOPARTICULES D'ACIDE TANNIQUE/FE (III) ET PROCÉDÉS D'ADMINISTRATION DE MÉDICAMENT
Abstract
(EN)
Nanoparticle are described comprising a tannic acid, a trivalent metal ion, and a pharmaceutical agent comprising a water-soluble biologically active agent, such as a protein, a water-soluble peptide, small molecule or a combination thereof and methods of making and using the nanoparticles. Some nanoparticles of the present invention include 30-60% (w/w) of a tannic acid, 0.1-20% (w/w) of a trivalent metal ion, and 1-50% (w/w) of a pharmaceutical agent.
(FR)
L'invention concerne des nanoparticules comprenant un acide tannique, un ion métallique trivalent et un agent pharmaceutique comprenant un agent biologiquement actif hydrosoluble, tel qu'une protéine, un peptide soluble dans l'eau, une petite molécule ou une combinaison de ceux-ci et des procédés de fabrication et d'utilisation des nanoparticules. Certaines nanoparticules de la présente invention comprennent de 30 à 60 % (p/p) d'un acide tannique, de 0,1 à 20 % (p/p) d'un ion métallique trivalent, et de 1 à 50 % (p/p) d'un agent pharmaceutique.
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