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1. WO2020197934 - COMPOSITIONS AND METHODS FOR MODIFICATION OF TARGET MOLECULES

Publication Number WO/2020/197934
Publication Date 01.10.2020
International Application No. PCT/US2020/023634
International Filing Date 19.03.2020
IPC
C07K 1/107 2006.01
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
1General processes for the preparation of peptides
107by chemical modification of precursor peptides
A61K 47/62 2017.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
47Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
50the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
51the non-active ingredient being a modifying agent
62the modifying agent being a protein, peptide or polyamino acid
A61K 47/64 2017.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
47Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
50the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
51the non-active ingredient being a modifying agent
62the modifying agent being a protein, peptide or polyamino acid
64Drug-peptide, drug-protein or drug-polyamino acid conjugates, i.e. the modifying agent being a peptide, protein or polyamino acid which is covalently bonded or complexed to a therapeutically active agent
A61K 47/65 2017.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
47Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
50the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
51the non-active ingredient being a modifying agent
62the modifying agent being a protein, peptide or polyamino acid
65Peptidic linkers, binders or spacers, e.g. peptidic enzyme-labile linkers
Applicants
  • THE REGENTS OF THE UNIVERSITY OF CALIFORNIA [US]/[US]
Inventors
  • FRANCIS, Matthew B.
  • LOBBA, Marco Jackson
  • MAZA, Johnathan Charles
  • MARMELSTEIN, Alan M.
  • DOUDNA, Jennifer A.
  • FELLMANN, Christof
  • MOGILEVSKY, Casey S.
Agents
  • BORDEN, Paula A.
Priority Data
62/822,61622.03.2019US
62/910,83604.10.2019US
Publication Language English (EN)
Filing Language English (EN)
Designated States
Title
(EN) COMPOSITIONS AND METHODS FOR MODIFICATION OF TARGET MOLECULES
(FR) COMPOSITIONS ET PROCÉDÉS DE MODIFICATION DE MOLÉCULES CIBLES
Abstract
(EN)
The present disclosure provides a method for chemoselective modification of a target molecule. A subject method includes contacting a target molecule comprising a thiol moiety with a biomolecule comprising a reactive moiety, wherein the reactive moiety is generated by reaction of a biomolecule comprising a phenol moiety or a catechol with an enzyme capable of oxidizing the phenol or the catechol moiety. The contacting is carried out under conditions sufficient for conjugation of the target molecule to the biomolecule, thereby producing a modified target molecule. The present disclosure provides compositions comprising a subject target molecule comprising a thiol moiety, and a biomolecule comprising a phenol moiety or a catechol moiety. The present disclosure provides kits for carrying out a subject method. The present disclosure also provides modified target molecules and methods for using same.
(FR)
La présente invention concerne un procédé de modification chimiosélective d'une molécule cible. Un procédé selon l'invention comprend la mise en contact d'une molécule cible comprenant une fraction thiol avec une biomolécule comprenant une fraction réactive, la fraction réactive étant générée par la réaction d'une biomolécule comprenant une fraction phénol ou catéchol avec une enzyme capable d'oxyder la fraction phénol ou catéchol. La mise en contact est réalisée dans des conditions suffisantes pour la conjugaison de la molécule cible avec la biomolécule, produisant ainsi une molécule cible modifiée. La présente invention concerne des compositions comprenant une molécule cible selon l'invention comprenant une fraction thiol, et une biomolécule comprenant une fraction phénol ou une fraction catéchol. La présente invention concerne également des kits pour la mise en œuvre d'un procédé selon l'invention. La présente invention concerne également des molécules cibles modifiées et leurs procédés d'utilisation.
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