Processing

Please wait...

Settings

Settings

Goto Application

1. WO2020197656 - SYSTEM AND METHOD FOR FABRICATION OF LARGE, POROUS DRUG-SILK MATERIALS USING CRYOGRANULATION

Publication Number WO/2020/197656
Publication Date 01.10.2020
International Application No. PCT/US2020/018006
International Filing Date 12.02.2020
IPC
A61L 27/28 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
LMETHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION, OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS, OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS, OR SURGICAL ARTICLES
27Materials for prostheses or for coating prostheses
28Materials for coating prostheses
A61L 27/34 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
LMETHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION, OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS, OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS, OR SURGICAL ARTICLES
27Materials for prostheses or for coating prostheses
28Materials for coating prostheses
34Macromolecular materials
A61L 27/54 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
LMETHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION, OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS, OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS, OR SURGICAL ARTICLES
27Materials for prostheses or for coating prostheses
50Materials characterised by their function or physical properties
54Biologically active materials, e.g. therapeutic substances
Applicants
  • TRUSTEES OF TUFTS COLLEGE [US]/[US]
Inventors
  • KAPLAN, David, L.
  • RODIONOV, Ilia, A.
Agents
  • GRAVES, John, M.
Priority Data
62/804,40612.02.2019US
Publication Language English (EN)
Filing Language English (EN)
Designated States
Title
(EN) SYSTEM AND METHOD FOR FABRICATION OF LARGE, POROUS DRUG-SILK MATERIALS USING CRYOGRANULATION
(FR) SYSTÈME ET PROCÉDÉ DE FABRICATION DE MATÉRIAUX À BASE DE SOIE-MÉDICAMENT POREUX DE GRANDE TAILLE À L'AIDE D'UNE CRYOGRANULATION
Abstract
(EN)
A method of making drug-eluting regenerated silk fibroin particles using cryogranulation. The method has a first step of injecting a mixture into a super-cooled fluid, the mixture including regenerated silk fibroin and at least one medicament. A second step of incubating the drug-eluting particles in the super-cooled fluid to promote cryogelation may also be used. The size distribution, morphology, and cross-linking efficiency of the particles can depend on several controllable variable, such as starting concentrations of cross-linking agents and silk fibroin in the mixture, the injection pressure, and the temperature of the super-cooled fluid.
(FR)
L'invention concerne un procédé de fabrication de particules de fibroïne de soie régénérée d'élution de médicament à l'aide d'une cryogranulation. Le procédé comprend une première étape d'injection d'un mélange dans un fluide super-refroidi, le mélange comprenant de la fibroïne de soie régénérée et au moins un médicament. Une seconde étape d'incubation des particules d'élution de médicament dans le fluide super-refroidi pour favoriser la cryogélification peut également être utilisée. La répartition de tailles, la morphologie et l'efficacité de réticulation des particules peuvent dépendre de plusieurs variables régulables, telles que les concentrations de départ d'agents de réticulation et de fibroïne de soie dans le mélange, la pression d'injection et la température du fluide super-refroidi.
Latest bibliographic data on file with the International Bureau