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1. WO2020197641 - DETECTION OF CARDIAC TROPONIN OR BIOLOGICAL MARKERS VIA SHEAR HORIZONTAL SURFACE ACOUSTIC WAVE BIOSENSOR USING A WET-DRY BIOANALYTICAL TECHNIQUE

Publication Number WO/2020/197641
Publication Date 01.10.2020
International Application No. PCT/US2020/016577
International Filing Date 04.02.2020
IPC
G01N 29/02 2006.01
GPHYSICS
01MEASURING; TESTING
NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
29Investigating or analysing materials by the use of ultrasonic, sonic or infrasonic waves; Visualisation of the interior of objects by transmitting ultrasonic or sonic waves through the object
02Analysing fluids
G01N 33/543 2006.01
GPHYSICS
01MEASURING; TESTING
NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
33Investigating or analysing materials by specific methods not covered by groups G01N1/-G01N31/131
48Biological material, e.g. blood, urine; Haemocytometers
50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
53Immunoassay; Biospecific binding assay; Materials therefor
543with an insoluble carrier for immobilising immunochemicals
CPC
A61B 5/0402
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
BDIAGNOSIS; SURGERY; IDENTIFICATION
5Detecting, measuring or recording for diagnostic purposes
04Measuring bioelectric signals of the body or parts thereof
0402Electrocardiography, i.e. ECG
G01N 2291/0255
GPHYSICS
01MEASURING; TESTING
NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
2291Indexing codes associated with group G01N29/00
02Indexing codes associated with the analysed material
025Change of phase or condition
0255(Bio)chemical reactions, e.g. on biosensors
G01N 2291/02809
GPHYSICS
01MEASURING; TESTING
NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
2291Indexing codes associated with group G01N29/00
02Indexing codes associated with the analysed material
028Material parameters
02809Concentration of a compound, e.g. measured by a surface mass change
G01N 29/022
GPHYSICS
01MEASURING; TESTING
NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
29Investigating or analysing materials by the use of ultrasonic, sonic or infrasonic waves; Visualisation of the interior of objects by transmitting ultrasonic or sonic waves through the object
02Analysing fluids
022Fluid sensors based on microsensors, e.g. quartz crystal-microbalance [QCM], surface acoustic wave [SAW] devices, tuning forks, cantilevers, flexural plate wave [FPW] devices
G01N 33/536
GPHYSICS
01MEASURING; TESTING
NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
33Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
48Biological material, e.g. blood, urine
50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
53Immunoassay; Biospecific binding assay; Materials therefor
536with immune complex formed in liquid phase
Applicants
  • SENSOR KINESIS CORPORATION [US]/[US]
  • SHACHAR, Yehoshua [US]/[US]
  • THOMAS, Marlon [US]/[US]
Inventors
  • SHACHAR, Yehoshua
  • THOMAS, Marlon
Agents
  • DAWES, Marcus
  • DAWES, Daniel
Priority Data
16/368,58328.03.2019US
Publication Language English (EN)
Filing Language English (EN)
Designated States
Title
(EN) DETECTION OF CARDIAC TROPONIN OR BIOLOGICAL MARKERS VIA SHEAR HORIZONTAL SURFACE ACOUSTIC WAVE BIOSENSOR USING A WET-DRY BIOANALYTICAL TECHNIQUE
(FR) DÉTECTION DE TROPONINE CARDIAQUE OU DE MARQUEURS BIOLOGIQUES PAR L'INTERMÉDIAIRE D'UN BIOCAPTEUR À ONDES ACOUSTIQUES DE SURFACE HORIZONTALE DE CISAILLEMENT À L'AIDE D'UNE TECHNIQUE D’ANALYSE BIOLOGIQUE PAR VOIE HUMIDE ET SÈCHE
Abstract
(EN)
The illustrated embodiments include a method of operating a SAW sensor to detect a sample in a fluid which includes the steps of: providing a SAW sensor with a functionalized detection lane in a handheld, portable assay and sensor system; maintaining the functionalized detection lane of the SAW sensor dry until the sample is fluidicly disposed in the detection lane; fluidicly disposing the sample in the functionalized detection lane; removing fluid the functionalized detection lane to concentrate the sample in the functionalized detection lane to increase the probability of a specific antibody-antigen interaction; washing the functionalized detection lane so that substantially only the specific antigen-antibody interaction remains in the functionalized detection lane; removing fluid from the functionalized detection lane again; and measuring concentration of the sample while the functionalized detection lane is fluid-free.
(FR)
L’invention concerne, selon des modes de réalisation illustrés, un procédé de fonctionnement d'un capteur à ondes acoustiques de surface (SAW) servant à détecter un échantillon dans un fluide qui comprend les étapes consistant à : fournir un capteur SAW avec une voie de détection fonctionnalisée dans un système de capteur et d’essai portable que l’on tient à la main ; maintenir la voie de détection fonctionnalisée du capteur SAW à sec jusqu'à ce que l'échantillon soit disposé de manière fluidique dans la voie de détection ; disposer l'échantillon de manière fluidique dans la voie de détection fonctionnalisée ; retirer le fluide de la voie de détection fonctionnalisée afin de concentrer l'échantillon dans la voie de détection fonctionnalisée pour augmenter la probabilité d'une interaction spécifique anticorps-antigène ; laver la voie de détection fonctionnalisée de telle sorte que sensiblement seule l'interaction antigène-anticorps spécifique demeure dans la voie de détection fonctionnalisée ; retirer à nouveau le fluide de la voie de détection fonctionnalisée ; et mesurer la concentration de l'échantillon pendant que la voie de détection fonctionnalisée est exempte de fluide.
Also published as
Latest bibliographic data on file with the International Bureau