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1. WO2020197332 - COMPOSITION FOR PREVENTING OR TREATING NEUROINFLAMMATORY DISORDERS, COMPRISING BEE VENOM EXTRACT AS ACTIVE INGREDIENT

Publication Number WO/2020/197332
Publication Date 01.10.2020
International Application No. PCT/KR2020/004239
International Filing Date 27.03.2020
IPC
A61K 35/64 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
35Medicinal preparations containing materials or reaction products thereof with undetermined constitution
56Materials from animals other than mammals
63Arthropods
64Insects, e.g. bees, wasps or fleas
A61K 38/46 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
38Medicinal preparations containing peptides
16Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
43Enzymes; Proenzymes; Derivatives thereof
46Hydrolases (3)
A61P 25/28 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
25Drugs for disorders of the nervous system
28for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
A23L 33/10 2016.01
AHUMAN NECESSITIES
23FOODS OR FOODSTUFFS; THEIR TREATMENT, NOT COVERED BY OTHER CLASSES
LFOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D91; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
33Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
10using additives
Applicants
  • 이니스트에스티 주식회사 INIST ST CO., LTD. [KR]/[KR]
Inventors
  • 김국현 KIM, Kuk Hyun
  • 이해인 RHEE, Hae In
  • 김세현 KIM, Sehyun
Agents
  • 특허법인 태백 TAEBAEK INTELLECTUAL PROPERTY LAW FIRM
Priority Data
10-2019-003609228.03.2019KR
10-2020-003691226.03.2020KR
Publication Language Korean (KO)
Filing Language Korean (KO)
Designated States
Title
(EN) COMPOSITION FOR PREVENTING OR TREATING NEUROINFLAMMATORY DISORDERS, COMPRISING BEE VENOM EXTRACT AS ACTIVE INGREDIENT
(FR) COMPOSITION POUR PRÉVENIR OU TRAITER LES TROUBLES NEUROINFLAMMATOIRES, COMPRENANT UN EXTRAIT DE VENIN D'ABEILLE EN TANT QUE PRINCIPE ACTIF
(KO) 봉독 추출물을 유효성분으로 함유하는 신경염증 질환 예방 또는 치료용 조성물
Abstract
(EN)
The present invention relates to a composition for preventing or treating neuroinflammatory disorders, comprising a bee venom extract as an active ingredient. More specifically, the present invention provides a pharmaceutical composition or a health functional food composition for preventing or treating neuroinflammatory disorders, both of which comprise, as an active ingredient, a bee venom extract in which the amount of phospholipase A2 (PLA2) is 50 to 85%. The bee venom extract alleviates decreased motor functions caused by neurotoxicity and has neuroprotective and neuroinflammation-relieving effects, thereby enabling the prevention or treatment of neuroinflammatory disorders. Particularly, a pharmaceutical composition according to the present invention can further improve an effect of preventing or treating neuroinflammatory disorders by being subcutaneously administered or by being co-administered with a STAT3 inhibitor or an NF-κB inhibitor, thereby enabling more effective prevention or treatment of neuroinflammatory disorders.
(FR)
La présente invention concerne une composition pour la prévention ou le traitement de troubles neuroinflammatoires, comprenant un extrait de venin d'abeille en tant que principe actif. Plus spécifiquement, la présente invention concerne une composition pharmaceutique ou une composition d'aliment fonctionnel pour la santé pour prévenir ou traiter des troubles neuroinflammatoires, les deux comprenant, en tant que principe actif, un extrait de venin d'abeille dans lequel la quantité de phospholipase A2 (PLA2) est comprise entre 50 et 85 %. L'extrait de venin d'abeille atténue les fonctions motrices réduites provoquées par la neurotoxicité et présente des effets neuroprotecteurs et de soulagement de la neuro-inflammation, permettant ainsi la prévention ou le traitement de troubles neuroinflammatoires. En particulier, une composition pharmaceutique selon la présente invention peut en outre améliorer un effet de prévention ou de traitement de troubles neuroinflammatoires par administration sous-cutanée ou par co-administration avec un inhibiteur de STAT3 ou un inhibiteur de NF-κB, ce qui permet de prévenir ou de traiter plus efficacement des troubles neuroinflammatoires.
(KO)
본 발명은 봉독 추출물을 유효성분으로 함유하는 신경염증 질환 예방 또는 치료용 조성물에 관한 것으로, 보다 상세하게는 PLA2(phospholipase A2) 함량이 50 내지 85%인 봉독 추출물을 유효성분으로 함유하는 신경염증 질환 예방 또는 치료용 약학 조성물 또는 건강기능식품 조성물을 제공한다. 상기 봉독 추출물은 신경 독성에 의한 운동 기능 저하를 개선시키고, 신경보호 및 신경염증 완화 효과를 가짐으로써 신경염증 질환을 예방 또는 치료할 수 있다. 특히, 본 발명에 따른 약학 조성물은 피하 투여하거나 STAT3 억제제 또는 NF-κB 억제제와 병용함으로써 신경염증 질환의 예방 또는 치료 효과를 더욱 향상시킬 수 있어, 보다 효과적으로 신경염증 질환을 예방 또는 치료할 수 있다.
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