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1. WO2020197296 - COMPOSITION FOR PREVENTING OR TREATING GRAFT-VERSUS-HOST DISEASE COMPRISING TLR5 AGONIST DERIVED FROM FLAGELLIN AS EFFECTIVE COMPONENT

Publication Number WO/2020/197296
Publication Date 01.10.2020
International Application No. PCT/KR2020/004146
International Filing Date 26.03.2020
IPC
A61K 38/16 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
38Medicinal preparations containing peptides
16Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
A61P 37/06 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
37Drugs for immunological or allergic disorders
02Immunomodulators
06Immunosuppressants, e.g. drugs for graft rejection
A23L 33/195 2016.01
AHUMAN NECESSITIES
23FOODS OR FOODSTUFFS; THEIR TREATMENT, NOT COVERED BY OTHER CLASSES
LFOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D91; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
33Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
10using additives
17Amino acids, peptides or proteins
195Proteins from microorganisms
Applicants
  • 가톨릭대학교 산학협력단 THE CATHOLIC UNIVERSITY OF KOREA INDUSTRY-ACADEMIC COOPERATION FOUNDATION [KR]/[KR]
Inventors
  • 조석구 CHO, Seokgoo
  • 임건일 IM, Keonil
  • 김나연 KIM, Nayoun
  • 전영우 JEON, Youngwoo
  • 남영선 NAM, Youngsun
  • 송윤진 SONG, Yunejin
  • 이준석 LEE, Junseok
Agents
  • 특허법인 정안 HONESTY & JR PARTNERS INTELLECTUAL PROPERTY LAW GROUP
Priority Data
10-2019-003552128.03.2019KR
Publication Language Korean (KO)
Filing Language Korean (KO)
Designated States
Title
(EN) COMPOSITION FOR PREVENTING OR TREATING GRAFT-VERSUS-HOST DISEASE COMPRISING TLR5 AGONIST DERIVED FROM FLAGELLIN AS EFFECTIVE COMPONENT
(FR) COMPOSITION POUR PRÉVENIR OU TRAITER UNE MALADIE DU GREFFON CONTRE L'HÔTE COMPRENANT UN AGONISTE DE TLR5 DÉRIVÉ DE LA FLAGELLINE COMME COMPOSANT EFFICACE
(KO) 플라젤린으로부터 유도된 TLR5 작용제를 유효성분으로 포함하는 이식편대숙주질환의 예방 또는 치료용 조성물
Abstract
(EN)
The present invention relates to a composition for preventing or treating graft-versus-host disease (GVHD), comprising a TLR5 agonist derived from flagellin as an effective component. The TLR5 agonist derived from flagellin of the present invention exhibits an excellent therapeutic effect on GVHD, and thus may be developed as an active ingredient of a composition for the treatment, prevention, or alleviation of GVHD.
(FR)
La présente invention concerne une composition pour prévenir ou traiter une maladie du greffon contre l'hôte (GVHD), comprenant un agoniste de TLR5 dérivé de la flagelline comme composant efficace. L'agoniste de TLR5 dérivé de la flagelline selon la présente invention présente un excellent effet thérapeutique sur la GVHD, et peut donc être développé comme principe actif d'une composition pour le traitement, la prévention ou le soulagement de la GVHD.
(KO)
본 발명은 플라젤린으로부터 유도된 TLR5 작용제를 유효성분으로 포함하는 이식편대숙주질환의 예방 또는 치료용 조성물에 관한 것이다. 본 발명의 플라젤린으로부터 유도된 TLR5 작용제는 뛰어난 이식편대숙주질환(GVHD)의 치료 효과를 나타내므로, 이식편대숙주질환의 치료, 예방 또는 개선용 조성물의 활성성분으로 개발될 수 있다.
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