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1. WO2020197190 - METHOD FOR PREPARING BIOCOMPATIBLE POLYMER-BASED APIXABAN-LOADED MICROSPHERES

Publication Number WO/2020/197190
Publication Date 01.10.2020
International Application No. PCT/KR2020/003885
International Filing Date 20.03.2020
IPC
A61K 9/16 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
9Medicinal preparations characterised by special physical form
14Particulate form, e.g. powders
16Agglomerates; Granulates; Microbeadlets
A61K 31/437 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
33Heterocyclic compounds
395having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
435having six-membered rings with one nitrogen as the only ring hetero atom
4353ortho- or peri-condensed with heterocyclic ring systems
437the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
CPC
A61K 31/437
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
33Heterocyclic compounds
395having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
435having six-membered rings with one nitrogen as the only ring hetero atom
4353ortho- or peri-condensed with heterocyclic ring systems
437the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
A61K 9/1617
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
9Medicinal preparations characterised by special physical form
14Particulate form, e.g. powders, ; Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
16Agglomerates; Granulates; Microbeadlets ; ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
1605Excipients; Inactive ingredients
1617Organic compounds, e.g. phospholipids, fats
A61K 9/1682
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
9Medicinal preparations characterised by special physical form
14Particulate form, e.g. powders, ; Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
16Agglomerates; Granulates; Microbeadlets ; ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
1682Processes
Applicants
  • MEDIFORUM PHARM [KR]/[KR]
Inventors
  • JEONG, Dooyong
  • LEE, Sang-Hwi
  • KIM, Mijung
  • KIM, Ye-Ji
  • JOO, So Kyoung
  • PARK, Jae Hyung
  • KIM, Sae Jong
Agents
  • HANOL INTELLECTUAL PROPERTY AND LAW
Priority Data
10-2019-003535527.03.2019KR
Publication Language English (EN)
Filing Language English (EN)
Designated States
Title
(EN) METHOD FOR PREPARING BIOCOMPATIBLE POLYMER-BASED APIXABAN-LOADED MICROSPHERES
(FR) PROCÉDÉ DE PRÉPARATION DE MICROSPHÈRES CHARGÉES D'APIXABAN À BASE DE POLYMÈRE BIOCOMPATIBLE
Abstract
(EN)
The present invention relates to a method for preparing biocompatible polymer-based Apixaban-loaded microspheres. More specifically, the present invention relates to a method for preparing biocompatible polymer-based Apixaban-loaded microspheres, comprising: i) adding a fatty acid or triglyceride to a dispersed phase; and ii) preparing microspheres using a microfluidic method. The method for preparing biocompatible polymer-based Apixaban-loaded microspheres of the present invention can be effectively used in the preparation of microspheres in which Apixaban is stably encapsulated in high contents.
(FR)
La présente invention concerne un procédé de préparation de microsphères chargées d'apixaban à base de polymère biocompatible. Plus spécifiquement, la présente invention concerne un procédé de préparation de microsphères chargées d'apixaban à base de polymère biocompatible, comprenant : i) l'ajout d'un acide gras ou d'un triglycéride à une phase dispersée ; et ii) la préparation de microsphères à l'aide d'un procédé microfluidique. Le procédé de préparation de microsphères chargées d'apixaban à base de polymère biocompatible selon la présente invention peut être utilisé efficacement dans la préparation de microsphères dans lesquelles l'apixaban est encapsulé de manière stable dans des teneurs élevées.
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