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1. WO2020197059 - METHOD FOR INDUCING DIFFERENTIATION OF STEM CELLS INTO CARTILAGE CELLS, USING FOLIC ACID, FOLIC ACID DERIVATIVE, OR FOLIC ACID INHIBITOR

Publication Number WO/2020/197059
Publication Date 01.10.2020
International Application No. PCT/KR2020/000190
International Filing Date 06.01.2020
IPC
C12N 5/077 2010.01
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
5Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
07Animal cells or tissues
071Vertebrate cells or tissues, e.g. human cells or tissues
077Mesenchymal cells, e.g. bone cells, cartilage cells, marrow stromal cells, fat cells or muscle cells
Applicants
  • 이화여자대학교 산학협력단 EWHA UNIVERSITY - INDUSTRY COLLABORATION FOUNDATION [KR]/[KR]
Inventors
  • 정병문 JEONG, Byeongmoon
  • 문윤아 MOON, Yun-A
  • 엄소연 UM, Soyoun
Agents
  • 특허법인 엠에이피에스 MAPS INTELLECTUAL PROPERTY LAW FIRM
Priority Data
10-2019-003558028.03.2019KR
Publication Language Korean (KO)
Filing Language Korean (KO)
Designated States
Title
(EN) METHOD FOR INDUCING DIFFERENTIATION OF STEM CELLS INTO CARTILAGE CELLS, USING FOLIC ACID, FOLIC ACID DERIVATIVE, OR FOLIC ACID INHIBITOR
(FR) PROCÉDÉ PERMETTANT D'INDUIRE UNE DIFFÉRENCIATION DE CELLULES SOUCHES EN CELLULES CARTILAGINEUSES, À L'AIDE D'ACIDE FOLIQUE, D'UN DÉRIVÉ D'ACIDE FOLIQUE OU D'UN INHIBITEUR D'ACIDE FOLIQUE
(KO) 엽산, 엽산 유도체, 또는 엽산 저해제를 이용한 줄기세포의 연골세포로의 분화 유도 방법
Abstract
(EN)
The present invention relates to: a composition for inducing differentiation of stem cells into cartilage cells, comprising folic acid, a folic acid derivative, or a folic acid inhibitor; a method for inducing differentiation of stem cells into cartilage cells; and a pharmaceutical composition for treating cartilage-damaging diseases, comprising cartilage cells differentiated by the method for inducing differentiation.
(FR)
La présente invention concerne : une composition permettant d'induire une différenciation de cellules souches en cellules cartilagineuses, comprenant de l'acide folique, un dérivé d'acide folique ou un inhibiteur d'acide folique ; un procédé permettant d'induire une différenciation de cellules souches en cellules cartilagineuses ; et une composition pharmaceutique destinée au traitement de maladies endommageant le cartilage, contenant des cellules cartilagineuses différenciées par le procédé permettant d'induire une différenciation.
(KO)
엽산, 엽산 유도체, 또는 엽산 저해제를 포함하는 줄기세포의 연골세포로의 분화 유도용 조성물, 줄기세포의 연골세포로의 분화 유도 방법, 및 상기 분화 유도 방법에 의해 분화된 연골세포를 포함하는 연골 손상 질환 치료용 약학 조성물에 관한 것이다.
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