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1. WO2020196990 - IN VITRO OSTEOARTHRITIS MODEL AND METHOD FOR SCREENING FOR OSTEOARTHRITIS TREATMENT AGENT BY USING SAME

Publication Number WO/2020/196990
Publication Date 01.10.2020
International Application No. PCT/KR2019/007941
International Filing Date 01.07.2019
IPC
C12N 5/077 2010.01
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
5Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
07Animal cells or tissues
071Vertebrate cells or tissues, e.g. human cells or tissues
077Mesenchymal cells, e.g. bone cells, cartilage cells, marrow stromal cells, fat cells or muscle cells
G01N 33/50 2006.01
GPHYSICS
01MEASURING; TESTING
NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
33Investigating or analysing materials by specific methods not covered by groups G01N1/-G01N31/131
48Biological material, e.g. blood, urine; Haemocytometers
50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
Applicants
  • 박동휘 PARK, Donghwi [KR]/[KR]
Inventors
  • 박동휘 PARK, Donghwi
  • 한승우 HAN, Seung Woo
  • 정연관 JUNG, Youn-Kwan
Agents
  • 특허법인 무한 MUHANN PATENT & LAW FIRM
Priority Data
10-2019-003394925.03.2019KR
Publication Language Korean (KO)
Filing Language Korean (KO)
Designated States
Title
(EN) IN VITRO OSTEOARTHRITIS MODEL AND METHOD FOR SCREENING FOR OSTEOARTHRITIS TREATMENT AGENT BY USING SAME
(FR) MODÈLE D'OSTÉOARTHRITE IN VITRO ET PROCÉDÉ DE CRIBLAGE D'AGENT DE TRAITEMENT DE L'OSTÉOARTHRITE L'UTILISANT
(KO) 체외 골관절염 모델 및 이를 이용한 골관절염 치료제 스크리닝 방법
Abstract
(EN)
The present invention relates to an in vitro osteoarthritis experimental model and a method for screening for an osteoarthritis treatment agent by using same and, more specifically, to: an in vitro osteoarthritis model composition comprising chondroitin sulphate or a derivative thereof, chondrocytes, a cell culture medium, and a chondroitinase; an in vitro three-dimensional osteoarthritis model utilizing same; and a method for screening for an osteoarthritis treatment agent by using same.
(FR)
La présente invention concerne un modèle expérimental in vitro de l'ostéoarthrite et un procédé de criblage d'un agent de traitement de l'ostéoarthrite l'utilisant et, plus particulièrement, une composition de modèle d'ostéoarthrite in vitro comprenant du sulfate de chondroïtine ou un de ses dérivés, des chondrocytes, un milieu de culture cellulaire et une chondroïtinase; un modèle d'ostéoarthrite tridimensionnel in vitro l'utilisant; et un procédé de criblage d'un agent de traitement de l'ostéoarthrite les utilisant.
(KO)
본 발명은 생체 외 골관절염 실험 모델 및 이를 이용한 골관절염 치료제 스크리닝 방법에 관한 것으로, 보다 상세하게는 콘드로이틴 설페이트(chondroitin sulphate) 또는 이의 유도체; 연골세포(chondrocyte); 세포 배양 배지; 및 콘드로이티나제(chondroitinase)를 포함하는 생체 외(in vitro) 골관절염 모델 조성물, 이를 활용한 생체 외 3차원 골관절염 모델 및 이를 이용한 골관절염 치료제 스크리닝 방법에 관한 것이다.
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