Processing

Please wait...

Settings

Settings

Goto Application

1. WO2020196852 - AQUEOUS FORMULATION

Publication Number WO/2020/196852
Publication Date 01.10.2020
International Application No. PCT/JP2020/014128
International Filing Date 27.03.2020
IPC
A61P 1/02 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
1Drugs for disorders of the alimentary tract or the digestive system
02Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis
A61P 17/00 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
17Drugs for dermatological disorders
A61Q 11/00 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
QSPECIFIC USE OF COSMETICS OR SIMILAR TOILET PREPARATIONS
11Preparations for care of the teeth, of the oral cavity or of dentures, e.g. dentifrices or toothpastes; Mouth rinses
A61Q 19/00 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
QSPECIFIC USE OF COSMETICS OR SIMILAR TOILET PREPARATIONS
19Preparations for care of the skin
A61K 9/08 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
9Medicinal preparations characterised by special physical form
08Solutions
A61K 8/39 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
8Cosmetics or similar toilet preparations
18characterised by the composition
30containing organic compounds
33containing oxygen
39Derivatives containing from 2 to 10 oxyalkylene groups
Applicants
  • 千寿製薬株式会社 SENJU PHARMACEUTICAL CO., LTD. [JP]/[JP]
Inventors
  • 澤 嗣郎 SAWA Shirou
Agents
  • 赤岡 和夫 AKAOKA Kazuo
  • 赤岡 迪夫 AKAOKA Michio
  • 吉岡 亜紀子 YOSHIOKA Akiko
Priority Data
2019-06026827.03.2019JP
Publication Language Japanese (JA)
Filing Language Japanese (JA)
Designated States
Title
(EN) AQUEOUS FORMULATION
(FR) FORMULATION AQUEUSE
(JA) 水性製剤
Abstract
(EN)
Provided is a stable aqueous formulation containing EPC-K. Also provided is a stablization method for the aqueous formulation containing the EPC-K. The aqueous formulation contains (a) dl-α-tocopherol-2-L-ascorbic acid phosphoric acid diester potassium salt and (b) at least one selected from the group consisting of polyoxyethylene alkyl phenyl ether, polyoxyethylene alkyl ether, and polyoxyethylene fatty acid ester. Moreover, the stabilization method for the aqueous formulation includes a step for preparing the aqueous formulation containing (a) dl-α-tocopherol-2-L-ascorbic acid phosphoric acid diester potassium salt and (b) at least one selected from the group consisting of polyoxyethylene alkyl phenyl ether, polyoxyethylene alkyl ether, and polyoxyethylene fatty acid ester.
(FR)
L'invention concerne une formulation aqueuse stable contenant de l'EPC-K. L'invention concerne également un procédé de stabilisation de la formulation aqueuse contenant l'EPC-K. La formulation aqueuse contient (a) du sel de potassium de diester d'acide dl-α-tocophérol-2-L-ascorbique et d'acide phosphorique et (b) au moins un élément choisi dans le groupe constitué par un polyoxyéthylène alkyl phényl éther, un polyoxyéthylène alkyl éther et un ester d'acide gras de polyoxyéthylène. De plus, le procédé de stabilisation de la formulation aqueuse comprend une étape de préparation de la formulation aqueuse contenant (a) du sel de potassium de diester d'acide dl-α-tocophérol-2-L-ascorbique et d'acide phosphorique et (b) au moins un élément choisi dans le groupe constitué par un polyoxyéthylène alkyl phényl éther, un polyoxyéthylène alkyl éther et un ester d'acide gras de polyoxyéthylène.
(JA)
EPC-Kを含有する安定な水性製剤を提供する。また、EPC-Kを含有する水性製剤の安定化方法を提供する。水性製剤は、(a)dl-α-トコフェロール-2-L-アスコルビン酸リン酸ジエステルカリウム塩と、(b)ポリオキシエチレンアルキルフェニルエーテル、ポリオキシエチレンアルキルエーテル、および、ポリオキシエチレン脂肪酸エステルからなる群から選択される少なくともいずれか1つとを含む。また、水性製剤の安定化方法は、(a)dl-α-トコフェロール-2-L-アスコルビン酸リン酸ジエステルカリウム塩と、(b)ポリオキシエチレンアルキルフェニルエーテル、ポリオキシエチレンアルキルエーテル、および、ポリオキシエチレン脂肪酸エステルからなる群から選択される少なくともいずれか1つとを含む水性製剤を調製する工程を含む。
Latest bibliographic data on file with the International Bureau