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1. WO2020196828 - NITROGEN-CONTAINING HETEROCYCLIC COMPOUND

Publication Number WO/2020/196828
Publication Date 01.10.2020
International Application No. PCT/JP2020/013982
International Filing Date 27.03.2020
IPC
A61P 25/04 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
25Drugs for disorders of the nervous system
04Centrally acting analgesics, e.g. opioids
A61P 25/06 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
25Drugs for disorders of the nervous system
06Antimigraine agents
A61P 25/24 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
25Drugs for disorders of the nervous system
24Antidepressants
A61P 25/28 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
25Drugs for disorders of the nervous system
28for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
A61P 43/00 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
43Drugs for specific purposes, not provided for in groups A61P1/-A61P41/108
C07D 471/04 2006.01
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
471Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/-C07D463/251
02in which the condensed system contains two hetero rings
04Ortho-condensed systems
Applicants
  • 武田薬品工業株式会社 TAKEDA PHARMACEUTICAL COMPANY LIMITED [JP]/[JP]
Inventors
  • 池田 周平 IKEDA, Shuhei
  • 鎌田 信 KAMATA, Makoto
  • 帆足 保孝 HOASHI, Yasutaka
  • 山下 徹 YAMASHITA, Tohru
  • 蓮井 智章 HASUI, Tomoaki
  • 喜名 朝人 KINA, Asato
  • 大仁 將揮 DAINI, Masaki
  • 筧 広行 KAKEI, Hiroyuki
  • ▲高▼嶋 幸恵 TAKASHIMA, Sachie
  • 森本 真二 MORIMOTO, Shinji
  • 伊藤 光博 ITO, Mitsuhiro
  • 倉澤 修 KURASAWA, Osamu
  • 米森 仁一 YONEMORI, Jinichi
Agents
  • 高島 一 TAKASHIMA, Hajime
Priority Data
2019-06340428.03.2019JP
Publication Language Japanese (JA)
Filing Language Japanese (JA)
Designated States
Title
(EN) NITROGEN-CONTAINING HETEROCYCLIC COMPOUND
(FR) COMPOSÉ HÉTÉROCYCLIQUE CONTENANT DE L'AZOTE
(JA) 含窒素複素環化合物
Abstract
(EN)
This nitrogen-containing heterocyclic compound can have an NMDA receptor antagonistic effect and is expected to be useful as a preventive or therapeutic agent for depression (including severe depression, refractory severe depression, and treatment-resistant depression), bipolar disorder, migraines, aches, peripheral symptoms of dementia and the like. Provided is a compound represented by formula (I) (where each symbol is as defined in the description), or a salt thereof.
(FR)
Ce composé hétérocyclique contenant de l'azote peut avoir un effet antagoniste du récepteur NMDA et est censé être utile en tant qu'agent préventif ou thérapeutique de la dépression (y compris une dépression grave, une dépression grave réfractaire et une dépression résistante au traitement), un trouble bipolaire, des migraines, des douleurs continues, des symptômes périphériques de la démence et analogues. L'invention concerne un composé représenté par la formule (I) (dans laquelle chaque symbole est tel que défini dans la description), ou un sel de celui-ci.
(JA)
NMDA受容体の拮抗作用を有し得、うつ病(大うつ病、難治性大うつ病、治療抵抗性うつ病を含む)、双極性障害、片頭痛、疼痛、認知症周辺症状等の予防または治療剤として有用であることが期待される含窒素複素環化合物を提供すること。式(I): 〔式中、各記号は、明細書に記載の通りである。〕 で表される化合物またはその塩。
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