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1. WO2020196749 - EICOSAPENTAENOIC ACID ALKYL ESTER-CONTAINING COMPOSITION AND METHOD FOR PRODUCING SAME

Publication Number WO/2020/196749
Publication Date 01.10.2020
International Application No. PCT/JP2020/013656
International Filing Date 26.03.2020
IPC
C11B 7/00 2006.01
CCHEMISTRY; METALLURGY
11ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
BPRODUCING, e.g. BY PRESSING RAW MATERIALS OR BY EXTRACTION FROM WASTE MATERIALS, REFINING OR PRESERVING FATS, FATTY SUBSTANCES, e.g. LANOLIN, FATTY OILS OR WAXES; ESSENTIAL OILS; PERFUMES
7Separation of mixtures of fats or fatty oils into their constituents, e.g. saturated oils from unsaturated oils
C11C 1/00 2006.01
CCHEMISTRY; METALLURGY
11ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
CFATTY ACIDS OBTAINED FROM FATS, OILS OR WAXES; CANDLES; FATS, OILS OR FATTY ACIDS OBTAINED BY CHEMICAL MODIFICATION OF FATS, OILS OR FATTY ACIDS
1Preparation of fatty acids from fats, fatty oils, or waxes; Refining the fatty acids
A23L 33/12 2016.01
AHUMAN NECESSITIES
23FOODS OR FOODSTUFFS; THEIR TREATMENT, NOT COVERED BY OTHER CLASSES
LFOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D91; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
33Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
10using additives
115Fatty acids or derivatives thereof; Fats or oils
12Fatty acids or derivatives thereof
A61K 31/232 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
21Esters, e.g. nitroglycerine, selenocyanates
215of carboxylic acids
22of acyclic acids, e.g. pravastatin
23of acids having a carboxyl group bound to a chain of seven or more carbon atoms
232having three or more double bonds, e.g. etretinate
Applicants
  • 日清ファルマ株式会社 NISSHIN PHARMA INC. [JP]/[JP]
Inventors
  • 池本 裕之 IKEMOTO, Hiroyuki
  • 野出 純一 NODE, Junichi
  • 竹本 健二 TAKEMOTO, Kenji
Agents
  • 特許業務法人アルガ特許事務所 THE PATENT CORPORATE BODY ARUGA PATENT OFFICE
Priority Data
2019-05775426.03.2019JP
Publication Language Japanese (JA)
Filing Language Japanese (JA)
Designated States
Title
(EN) EICOSAPENTAENOIC ACID ALKYL ESTER-CONTAINING COMPOSITION AND METHOD FOR PRODUCING SAME
(FR) COMPOSITION CONTENANT UN ESTER ALKYLIQUE D'ACIDE EICOSAPENTAÉNOÏQUE ET PROCÉDÉ DE PRODUCTION D’UNE TELLE COMPOSITION
(JA) エイコサペンタエン酸アルキルエステル含有組成物の製造方法
Abstract
(EN)
In order to provide a method for producing high-purity EPA, the present invention provides a method for producing an EPA alkyl ester-containing composition which contains 96 mass% or more of an EPA alkyl ester in the total fatty acid content thereof, and in which the trans isomer ratio in the EPA alkyl ester is 1.5 mass% or less. This method includes: (1) preparing a raw material oil containing 50-92 mass% of an EPA alkyl ester in the total fatty acid content thereof; (2) bringing the raw material oil and an aqueous solution including a silver salt into contact, the mass ratio of a DHA alkyl ester with respect to the EPA alkyl ester contained in the raw material oil being 3.3 mass% or less, and the trans isomer ratio in the EPA alkyl ester contained in the raw material oil being 2 mass% or less; (3) recovering the aqueous solution including a silver salt brought into contact with the raw material oil; (4) bringing the recovered aqueous solution including the silver salt into contact with an organic solvent; and (5) recovering the organic solvent brought into contact with the aqueous solution including a silver salt.
(FR)
Afin de fournir un procédé de production d'EPA de haute pureté, la présente invention concerne un procédé de production d'une composition contenant un ester alkylique d'EPA qui contient 96 % en masse ou plus d'un ester alkylique d'EPA dans sa teneur totale en acides gras, et dans laquelle le rapport d’isomère trans dans l'ester alkylique d'EPA est inférieur ou égal à 1,5 % en masse. Le procédé consiste : (1) à préparer une huile de matière première contenant de 50 à 92 % en masse d'un ester alkylique d'EPA dans sa teneur totale en acide gras ; (2) à mettre en contact de l'huile de matière première et d'une solution aqueuse comprenant un sel d'argent, le rapport en masse d'un ester alkylique de DHA par rapport à l'ester alkylique d'EPA contenu dans l'huile de matière première étant inférieur ou égal à 3,3 % en masse, et le rapport d'isomère trans dans l'ester alkylique d'EPA contenu dans l'huile de matière première étant inférieur ou égal à 2 % en masse ; (3) à récupérer la solution aqueuse comprenant un sel d'argent mis en contact avec l'huile de matière première ; (4) à mettre en contact la solution aqueuse récupérée comprenant le sel d'argent avec un solvant organique ; et (5) à récupérer solvant organique mis en contact avec la solution aqueuse comprenant un sel d'argent.
(JA)
高純度なEPAを製造する方法の提供。EPAアルキルエステルを全脂肪酸中に96質量%以上含有し、且つEPAアルキルエステル中のトランス異性体の比率が1.5質量%以下であるEPAアルキルエステル含有組成物の製造方法。本方法は、(1)EPAアルキルエステルを全脂肪酸中に50~92質量%含有する原料油を準備すること、該原料油に含有されるEPAアルキルエステルに対するDHA酸アルキルエステルの質量比は3.3質量%以下であり、かつ該原料油に含有されるEPAアルキルエステル中のトランス異性体の比率は2質量%以下である;(2)該原料油と、銀塩を含む水性溶液とを接触させること;(3)該原料油と接触させた銀塩を含む水性溶液を回収すること;(4)回収した銀塩を含む水性溶液と、有機溶媒とを接触させること;及び、(5)該銀塩を含む水性溶液と接触させた有機溶媒を回収することを含む。
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