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1. WO2020196678 - BRAIN BLOOD VESSEL MODEL AND DEVICE

Publication Number WO/2020/196678
Publication Date 01.10.2020
International Application No. PCT/JP2020/013477
International Filing Date 25.03.2020
IPC
C12M 3/00 2006.01
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
MAPPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY
3Tissue, human, animal or plant cell, or virus culture apparatus
C12N 5/071 2010.01
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
5Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
07Animal cells or tissues
071Vertebrate cells or tissues, e.g. human cells or tissues
Applicants
  • 国立大学法人大阪大学 OSAKA UNIVERSITY [JP]/[JP]
Inventors
  • 松▲崎▼ 典弥 MATSUSAKI Michiya
  • フィガロル アガット エリザベス マリー FIGAROL Agathe Elisabeth Marie
  • 佐藤 薫 SATO Kaoru
Agents
  • 長谷川 芳樹 HASEGAWA Yoshiki
  • 諏澤 勇司 SUZAWA Yuji
Priority Data
2019-06132627.03.2019JP
Publication Language Japanese (JA)
Filing Language Japanese (JA)
Designated States
Title
(EN) BRAIN BLOOD VESSEL MODEL AND DEVICE
(FR) MODÈLE ET DISPOSITIF DE VAISSEAU SANGUIN CÉRÉBRAL
(JA) 脳血管モデル及びデバイス
Abstract
(EN)
Disclosed is a brain blood vessel model that comprises a three-dimensional tissue body that includes a fibrillated extracellular matrix component and cells that include brain microvascular endothelial cells, pericytes, and astroglia, at least a portion of the cells being adhered to the fibrillated extracellular matrix.
(FR)
L'invention concerne un modèle de vaisseau sanguin cérébral qui comprend un corps de tissu tridimensionnel incluant un composant de matrice extracellulaire fibrillée et des cellules qui comprennent des cellules endothéliales microvasculaires cérébrales, des péricytes et des astroglies, au moins une partie des cellules étant collée à la matrice extracellulaire fibrillée.
(JA)
解繊された細胞外マトリックス成分と、脳毛細血管内皮細胞、周皮細胞、及び星状膠細胞を含む細胞とを含み、上記細胞の少なくとも一部が上記解繊された細胞外マトリックス成分に接着している三次元組織体からなる、脳血管モデル、を開示する。
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