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1. WO2020196437 - METHOD FOR ASSISTING EVALUATION OF RENAL PATHOLOGICAL CONDITIONS, SYSTEM FOR EVALUATING RENAL PATHOLOGICAL CONDITIONS AND PROGRAM FOR EVALUATING RENAL PATHOLOGICAL CONDITIONS

Publication Number WO/2020/196437
Publication Date 01.10.2020
International Application No. PCT/JP2020/012807
International Filing Date 23.03.2020
IPC
G01N 33/15 2006.01
GPHYSICS
01MEASURING; TESTING
NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
33Investigating or analysing materials by specific methods not covered by groups G01N1/-G01N31/131
15Medicinal preparations
G01N 33/493 2006.01
GPHYSICS
01MEASURING; TESTING
NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
33Investigating or analysing materials by specific methods not covered by groups G01N1/-G01N31/131
48Biological material, e.g. blood, urine; Haemocytometers
483Physical analysis of biological material
487of liquid biological material
493urine
G01N 33/50 2006.01
GPHYSICS
01MEASURING; TESTING
NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
33Investigating or analysing materials by specific methods not covered by groups G01N1/-G01N31/131
48Biological material, e.g. blood, urine; Haemocytometers
50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
G01N 33/68 2006.01
GPHYSICS
01MEASURING; TESTING
NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
33Investigating or analysing materials by specific methods not covered by groups G01N1/-G01N31/131
48Biological material, e.g. blood, urine; Haemocytometers
50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
68involving proteins, peptides or amino acids
Applicants
  • KAGAMI株式会社 KAGAMI INC. [JP]/[JP]
  • 国立研究開発法人医薬基盤・健康・栄養研究所 NATIONAL INSTITUTES OF BIOMEDICAL INNOVATION, HEALTH AND NUTRITION [JP]/[JP]
Inventors
  • 三田 真史 MITA, Masashi
  • 池田 達彦 IKEDA, Tatsuhiko
  • 木村 友則 KIMURA, Tomonori
Agents
  • 青木 篤 AOKI, Atsushi
  • 三橋 真二 MITSUHASHI, Shinji
  • 渡辺 陽一 WATANABE, Yoichi
  • 中島 勝 NAKAJIMA, Masaru
  • 武居 良太郎 TAKEI, Ryotaro
  • 柴田 潤二 SHIBATA, Junji
Priority Data
2019-05574422.03.2019JP
2019-05735725.03.2019JP
Publication Language Japanese (JA)
Filing Language Japanese (JA)
Designated States
Title
(EN) METHOD FOR ASSISTING EVALUATION OF RENAL PATHOLOGICAL CONDITIONS, SYSTEM FOR EVALUATING RENAL PATHOLOGICAL CONDITIONS AND PROGRAM FOR EVALUATING RENAL PATHOLOGICAL CONDITIONS
(FR) MÉTHODE D'AIDE À L'ÉVALUATION D'ÉTATS PATHOLOGIQUES RÉNAUX, SYSTÈME D'ÉVALUATION D'ÉTATS PATHOLOGIQUES RÉNAUX ET PROGRAMME D'ÉVALUATION D'ÉTATS PATHOLOGIQUES RÉNAUX
(JA) 腎病態の評価を補助する方法、腎病態の評価システム及び腎病態の評価プログラム
Abstract
(EN)
The present invention provides: a method for assisting the evaluation of renal pathological conditions, said method comprising using, as an index, a combination of renal reabsorption and excretion ratios of D-serine and/or D-asparagine in a subject with the blood D-serine and/or D-asparagine levels; a system for evaluating renal pathological conditions; and a program for evaluating renal pathological conditions. The present invention also provides: a method for monitoring renal pathological conditions; and a method for monitoring an effect of treating a renal disease.
(FR)
La présente invention concerne : une méthode d'aide à l'évaluation d'états pathologiques rénaux, ladite méthode comprenant l'utilisation, en tant qu'indice, d'une combinaison du taux de réabsorption et d'excrétion rénale de D-sérine et/ou de D-asparagine chez un sujet avec les taux de D-sérine et/ou de D-asparagine sanguins ; un système permettant d'évaluer des états pathologiques rénaux ; et un programme permettant d'évaluer des états pathologiques rénaux. La présente invention concerne également : une méthode de surveillance d'états pathologiques rénaux ; et une méthode de surveillance d'un effet de traitement d'une maladie rénale.
(JA)
本発明は、対象の腎臓におけるD-セリン及び/又はD-アスパラギンの再吸収及び排泄の割合と、血液中D-セリン量及び/又はD-アスパラギン量との組み合わせを指標とする、腎病態の評価を補助する方法、腎病態の評価システム及び腎病態の評価プログラムを提供する。また、本発明は、腎病態をモニタリングする方法及び腎臓病の治療効果をモニタリングする方法も提供する。
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