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1. WO2020196381 - INFUSION FOR SUBCUTANEOUS ADMINISTRATION

Publication Number WO/2020/196381
Publication Date 01.10.2020
International Application No. PCT/JP2020/012649
International Filing Date 23.03.2020
IPC
A61P 7/08 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
7Drugs for disorders of the blood or the extracellular fluid
08Plasma substitutes; Perfusion solutions; Dialytics or haemodialytics; Drugs for electrolytic or acid-base disorders, e.g. hypovolemic shock
A61K 9/08 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
9Medicinal preparations characterised by special physical form
08Solutions
A61K 47/02 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
47Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
02Inorganic compounds
A61K 47/12 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
47Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
06Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
08containing oxygen
12Carboxylic acids; Salts or anhydrides thereof
Applicants
  • 株式会社大塚製薬工場 OTSUKA PHARMACEUTICAL FACTORY, INC. [JP]/[JP]
Inventors
  • 小林 只 KOBAYASHI, Tadashi
  • 米田 博輝 MAITA, Hiroki
  • 大室 秀樹 OHMURO, Hideki
  • 廣田 祐輔 HIROTA, Yusuke
  • 原田 大輔 HARADA, Daisuke
  • 林 洸仁 HAYASHI, Takehito
  • 森田 知樹 MORITA, Tomoki
  • 品川 義之 SHINAGAWA, Yoshiyuki
Agents
  • 田中 順也 TANAKA, Junya
  • 水谷 馨也 MIZUTANI, Keiya
  • 迫田 恭子 SAKODA, Kyoko
Priority Data
2019-06448728.03.2019JP
2019-19400825.10.2019JP
Publication Language Japanese (JA)
Filing Language Japanese (JA)
Designated States
Title
(EN) INFUSION FOR SUBCUTANEOUS ADMINISTRATION
(FR) PERFUSION POUR ADMINISTRATION SOUS-CUTANÉE
(JA) 皮下投与用輸液
Abstract
(EN)
An objective of the present invention is to provide an infusion of improved subcutaneous diffusivity. Bicarbonate ions are included in the infusion for subcutaneous administration to improve the subcutaneous diffusivity of the infusion for subcutaneous administration. The infusion for subcutaneous administration is preferably in the form of Ringer's solution having a bicarbonate ion concentration of 10–50 mEq/L, a pH of 6.0–8.5, an osmolality ratio of 0.8–1.3 with respect to the osmolality of normal saline, and a dosage of 20–1500 ml/day, and can further contain sodium ions, potassium ions, calcium ions, magnesium ions, and citrate ions.
(FR)
Un objectif de la présente invention est de fournir une perfusion à diffusivité sous-cutanée améliorée. Des ions bicarbonate sont inclus dans la perfusion pour une administration sous-cutanée afin d'améliorer la diffusivité sous-cutanée de la perfusion pour une administration sous-cutanée. La perfusion pour administration sous-cutanée se présente de préférence sous la forme d'une solution de Ringer ayant une concentration en ions bicarbonate de 10 à 50 mEq/L, un pH de 6,0 à 8,5, un rapport d'osmolalité de 0,8 à 1,3 par rapport à l'osmolalité d'une solution saline normale, et une posologie de 20 à 1 500 ml/jour, et peut en outre contenir des ions sodium, des ions potassium, des ions calcium, des ions magnésium et des ions citrate.
(JA)
本発明は、皮下拡散性が向上した輸液を提供することを目的とする。皮下投与用輸液において重炭酸イオンを配合することで、皮下投与用輸液の皮下拡散性が向上する。皮下投与用輸液は、好ましくは、重炭酸イオンの濃度が10~50mEq/L、pHが6.0~8.5、生理食塩水の浸透圧に対する浸透圧比が0.8~1.3、投与量が20~1500ml/日であり、リンゲル液の形態であり、更に、ナトリウムイオン、カリウムイオン、カルシウムイオン、マグネシウムイオン、クエン酸イオンを含むことができる。
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